{"id":"W2010457667","doi":"10.1038/cddis.2010.21","title":"Histone deacetylase 1 and 2 differentially regulate apoptosis by opposing effects on extracellular signal-regulated kinase 1/2","year":2010,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Biological Sciences","funders":"National Key Research and Development Program of China; National Natural Science Foundation of China","keywords":"Cell biology; Biology; HDAC1; Apoptosis; Signal transduction; Histone deacetylase 2; RNA interference; Downregulation and upregulation; ASK1; Transforming growth factor; Cancer research; Kinase; Histone deacetylase; Histone; Protein kinase A; Mitogen-activated protein kinase kinase; Biochemistry; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001504982,0.000361982,0.0003692255,0.0002039012,0.0001702916,0.0004453209,0.0002135373,0.0002461453,0.001499366],"category_scores_gemma":[0.0001190826,0.0002165073,0.0004251099,0.0001490049,0.0001914127,0.000267859,0.0001985651,0.0005347616,0.0003815308],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003283547,"about_ca_system_score_gemma":0.000204892,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003257096,"about_ca_topic_score_gemma":0.0007328287,"domain_scores_codex":[0.9997863,0.0000205827,0.00001665374,0.00005402595,0.00005322001,0.00006913069],"domain_scores_gemma":[0.9999379,0.000005948618,0.00002102927,0.000006621458,0.00001119765,0.00001740761],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003365059,0.00003315823,0.0007033124,0.0000581661,0.00001780496,0.00005830872,0.00001537291,0.0000800434,0.9954983,0.0002595539,0.0001125758,0.002826804],"study_design_scores_gemma":[0.000120237,0.000393936,0.02272651,0.00001270791,0.00009669786,0.0005586319,0.00006881924,0.001483825,0.9657245,0.0001990014,0.008600605,0.00001457754],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9850712,0.007408946,0.003185696,0.0002367804,0.0001358684,0.00003531743,0.0004122386,0.00009789238,0.003416105],"genre_scores_gemma":[0.9903139,0.002656251,0.001314179,0.0001517794,0.00004284586,0.00004990697,0.0005688586,0.00002459497,0.004877488],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001499366,"threshold_uncertainty_score":0.00501585,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004855283115962289,"score_gpt":0.2320151280267104,"score_spread":0.2271598449107481,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}