{"id":"W2010476245","doi":"10.1016/j.neuro.2004.02.002","title":"Overexpression of Metallothionein Protects Cultured Motor Neurons Against Oxidative Stress, but not Mutant Cu/Zn-Superoxide Dismutase Toxicity","year":2004,"lang":"en","type":"article","venue":"NeuroToxicology","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University","funders":"","keywords":"SOD1; Oxidative stress; Amyotrophic lateral sclerosis; Metallothionein; Superoxide dismutase; Paraquat; Motor neuron; Glutamate receptor; Neurotoxicity; Downregulation and upregulation; Toxicity; Gene isoform; Chemistry; Cell biology; Biochemistry; Biology; Neuroscience; Internal medicine; Spinal cord; Medicine; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002132308,0.0004418876,0.0008628131,0.0002240111,0.0001841746,0.00002621033,0.0004144764,0.000403907,0.0002496829],"category_scores_gemma":[0.001170367,0.0003366949,0.000268346,0.0004117946,0.0005312151,0.0002300377,0.0004001034,0.001025597,0.00006378111],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002566946,"about_ca_system_score_gemma":0.0003524484,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001653019,"about_ca_topic_score_gemma":0.00003969564,"domain_scores_codex":[0.9962925,0.0004760238,0.0007096762,0.0008603323,0.0008550218,0.0008064388],"domain_scores_gemma":[0.9980329,0.0001724836,0.0002815899,0.0007725853,0.0002524019,0.0004880596],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001530469,0.001351042,0.0003568329,0.000162911,0.0000819757,0.0004145978,0.000259113,0.0002212894,0.9949234,0.0002755616,0.00008098353,0.0003418182],"study_design_scores_gemma":[0.004260096,0.00289232,0.04701676,0.0002731105,0.00005208988,0.00007577156,0.00005509038,0.0001956267,0.9445139,0.0001196723,0.0002915803,0.0002539664],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918684,0.00003137154,0.0001572628,0.002864081,0.0001412903,0.004202522,0.0002715323,0.0001459436,0.0003175625],"genre_scores_gemma":[0.9959784,0.00009844177,0.0009378433,0.00186441,0.0001482379,0.0005531714,0.00005808994,0.00007724881,0.0002841949],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05040948,"threshold_uncertainty_score":0.9999085,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0314096315228523,"score_gpt":0.2964677889387975,"score_spread":0.2650581574159452,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}