{"id":"W2010476245","doi":"10.1016/j.neuro.2004.02.002","title":"Overexpression of Metallothionein Protects Cultured Motor Neurons Against Oxidative Stress, but not Mutant Cu/Zn-Superoxide Dismutase Toxicity","year":2004,"lang":"en","type":"article","venue":"NeuroToxicology","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University","funders":"","keywords":"SOD1; Oxidative stress; Amyotrophic lateral sclerosis; Metallothionein; Superoxide dismutase; Paraquat; Motor neuron; Glutamate receptor; Neurotoxicity; Downregulation and upregulation; Toxicity; Gene isoform; Chemistry; Cell biology; Biochemistry; Biology; Neuroscience; Internal medicine; Spinal cord; Medicine; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000177986,0.0004689077,0.000473203,0.0002241221,0.0002917033,0.0003978162,0.0003471197,0.0004460589,0.001071451],"category_scores_gemma":[0.0001704115,0.0001874672,0.0003238996,0.0002426283,0.0003006771,0.0002983379,0.0002083816,0.0005533132,0.0003173847],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004890234,"about_ca_system_score_gemma":0.0004201198,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001559586,"about_ca_topic_score_gemma":0.002772297,"domain_scores_codex":[0.9998237,0.0000185107,0.00002774168,0.00004456375,0.00003659015,0.00004889658],"domain_scores_gemma":[0.9997649,0.00003341015,0.0000584082,0.00004481435,0.00003273749,0.00006576505],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003093301,0.00003001401,0.0001488869,0.00003213239,0.000008404664,0.0000607324,0.00001429548,0.00002691614,0.9989334,0.00002670123,0.00003224803,0.0003768441],"study_design_scores_gemma":[0.00002783284,0.0002570326,0.002663652,0.000005457658,0.00002184471,0.0001786437,0.00003201708,0.0002710945,0.9957922,0.00003152308,0.0007151329,0.000003690509],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978068,0.0005911867,0.0007644239,0.0000910227,0.00004314206,0.000008443731,0.0002274308,0.00007740386,0.0003900637],"genre_scores_gemma":[0.9936299,0.0005478029,0.001526071,0.00003738862,0.0000141906,0.00002463424,0.0009329036,0.00002990876,0.003257188],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001559586,"threshold_uncertainty_score":0.003584385,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0314096315228523,"score_gpt":0.2964677889387975,"score_spread":0.2650581574159452,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}