{"id":"W2010478401","doi":"10.1074/jbc.275.10.7337","title":"p53 Induces Apoptosis by Caspase Activation through Mitochondrial Cytochrome c Release","year":2000,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":564,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Cytochrome c; Apoptosis; Cell biology; Caspase; Mitochondrial apoptosis-induced channel; Apoptosome; Chemistry; Caspase 3; Mitochondrion; Caspase-9; Intrinsic apoptosis; Cytochrome; Molecular biology; Biology; Biochemistry; Programmed cell death; Enzyme","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001540947,0.0004948204,0.0002068475,0.0002357451,0.0001443979,0.0002609332,0.0001425256,0.0003082884,0.001062269],"category_scores_gemma":[0.0001512058,0.0001000722,0.0003313904,0.0001848905,0.0002115593,0.0002951884,0.0001883472,0.0007084564,0.0003750373],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002489304,"about_ca_system_score_gemma":0.0001618634,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002343194,"about_ca_topic_score_gemma":0.0002627719,"domain_scores_codex":[0.9998053,0.00002783713,0.00001791079,0.00003905075,0.00006633691,0.00004356343],"domain_scores_gemma":[0.9999143,0.00001838917,0.00002049886,0.00001570516,0.00001352523,0.000017678],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009208174,0.00002719941,0.0001449866,0.00003085976,0.000004408292,0.0001008386,0.00001161735,0.00002125962,0.9985206,0.00009391948,0.00002027464,0.000932001],"study_design_scores_gemma":[0.00003590175,0.0002897886,0.002918416,0.000005633772,0.00001175771,0.0004436371,0.00001473298,0.0005219762,0.994605,0.00008903896,0.001061409,0.000002674777],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909734,0.003007106,0.004145417,0.0001318243,0.00005481972,0.00002454008,0.0002241153,0.00005603491,0.001382744],"genre_scores_gemma":[0.9956632,0.001237849,0.001353704,0.00004056243,0.00001665434,0.00002095519,0.0004463433,0.000006488793,0.001214246],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001062269,"threshold_uncertainty_score":0.003553689,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02218740775139802,"score_gpt":0.2656794143092826,"score_spread":0.2434920065578846,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}