{"id":"W2010490561","doi":"10.1038/sj.bjc.6606053","title":"Attenuated reovirus displays oncolysis with reduced host toxicity","year":2010,"lang":"en","type":"article","venue":"British Journal of Cancer","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Dalhousie University; University of Calgary","funders":"National Cancer Institute; Fondation pour la Recherche Médicale; Canadian Institutes of Health Research; Terry Fox Foundation; University of Calgary","keywords":"Oncolytic virus; Biology; Virology; Cell culture; In vitro; Cancer cell; Pancreatic cancer; Cancer research; Virus; Cancer; Molecular biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001270083,0.000373858,0.0002240841,0.000190626,0.00007103688,0.0003498254,0.000192737,0.0003783243,0.0008797663],"category_scores_gemma":[0.0001703145,0.0001007429,0.0002186015,0.00009872581,0.0002036552,0.0001813225,0.0001342687,0.0005177403,0.0003015056],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002374437,"about_ca_system_score_gemma":0.0001446116,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003641118,"about_ca_topic_score_gemma":0.0003286432,"domain_scores_codex":[0.9998699,0.0000194154,0.00001140842,0.00002636396,0.0000438758,0.00002891215],"domain_scores_gemma":[0.9998122,0.00005466331,0.00004991464,0.00002744472,0.00002414796,0.00003155513],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005098772,0.00001625351,0.00006190125,0.00001274776,0.000002335367,0.00001663243,0.00000434753,0.00007171959,0.999223,0.00005056735,0.00001223537,0.0004772384],"study_design_scores_gemma":[0.000008579178,0.0003382665,0.0007780001,0.000003130506,0.00001006641,0.0002249162,0.000005328864,0.0005470243,0.9970191,0.00002351788,0.001039931,0.000002253198],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909389,0.001361739,0.005888057,0.00005171291,0.00002189119,0.00002374477,0.0002303711,0.0001137179,0.001369958],"genre_scores_gemma":[0.9937212,0.000405833,0.00318494,0.0000193821,0.000007044128,0.00001573375,0.0006753425,0.00004083804,0.001929704],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008797663,"threshold_uncertainty_score":0.002943099,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009718381219689641,"score_gpt":0.300131850537128,"score_spread":0.2904134693174384,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}