{"id":"W2010521246","doi":"10.1016/j.ygyno.2015.03.005","title":"A phase II study of single-agent RO4929097, a gamma-secretase inhibitor of Notch signaling, in patients with recurrent platinum-resistant epithelial ovarian cancer: A study of the Princess Margaret, Chicago and California phase II consortia","year":2015,"lang":"en","type":"article","venue":"Gynecologic Oncology","topic":"Developmental Biology and Gene Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":81,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital; Juravinski Cancer Centre; Ontario Institute for Cancer Research; University of Toronto; Princess Margaret Cancer Centre","funders":"National Cancer Institute","keywords":"Notch signaling pathway; Medicine; Epithelial ovarian cancer; Gamma secretase; Platinum; Internal medicine; Cancer research; Oncology; Ovarian cancer; Cancer; Cell biology; Receptor; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005483449,0.0002328172,0.0005506606,0.00008622465,0.0001174855,0.000003156833,0.0002207857,0.0002339515,0.00002237833],"category_scores_gemma":[0.0002099424,0.0001572431,0.00003884844,0.0002075969,0.0002853133,0.000006194166,0.0004029007,0.0001401523,2.136367e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001051648,"about_ca_system_score_gemma":0.0004081415,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001493639,"about_ca_topic_score_gemma":0.004434839,"domain_scores_codex":[0.997784,0.0005219743,0.000767645,0.0004584376,0.0002150584,0.0002529085],"domain_scores_gemma":[0.998584,0.00005622084,0.0007527813,0.0002839428,0.0002310143,0.0000919819],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01747501,0.06816113,0.587759,0.00006165236,0.0004781038,0.00001770303,0.005511687,0.000236101,0.2981475,0.000006585084,0.00008453641,0.02206098],"study_design_scores_gemma":[0.1106111,0.3755699,0.3756645,0.00009838086,0.0004263773,0.000007412485,0.005294065,0.00006880778,0.1296929,0.00005847843,0.001913864,0.0005941137],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973843,0.0001530832,0.000008039247,0.00005214402,0.000228052,0.001903012,0.0002323762,0.000005019081,0.00003398125],"genre_scores_gemma":[0.9995234,0.000008616107,0.0001402527,0.00003249704,0.00002716281,0.000140823,0.0001007746,0.00001111871,0.00001533235],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3074088,"threshold_uncertainty_score":0.6412187,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02085390900680943,"score_gpt":0.2876598021350212,"score_spread":0.2668058931282117,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}