{"id":"W2010521246","doi":"10.1016/j.ygyno.2015.03.005","title":"A phase II study of single-agent RO4929097, a gamma-secretase inhibitor of Notch signaling, in patients with recurrent platinum-resistant epithelial ovarian cancer: A study of the Princess Margaret, Chicago and California phase II consortia","year":2015,"lang":"en","type":"article","venue":"Gynecologic Oncology","topic":"Developmental Biology and Gene Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":81,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital; Juravinski Cancer Centre; Ontario Institute for Cancer Research; University of Toronto; Princess Margaret Cancer Centre","funders":"National Cancer Institute","keywords":"Notch signaling pathway; Medicine; Epithelial ovarian cancer; Gamma secretase; Platinum; Internal medicine; Cancer research; Oncology; Ovarian cancer; Cancer; Cell biology; Receptor; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002651953,0.001742852,0.002835868,0.0007259778,0.0006824909,0.001173998,0.001186807,0.002043713,0.003391176],"category_scores_gemma":[0.001467311,0.0008467525,0.002079374,0.0006507449,0.00146109,0.001296743,0.0004319198,0.003355532,0.0007810764],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00122544,"about_ca_system_score_gemma":0.002259055,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002401004,"about_ca_topic_score_gemma":0.005690316,"domain_scores_codex":[0.9992827,0.0003846455,0.00002998771,0.0001189667,0.00004942893,0.00013428],"domain_scores_gemma":[0.9984686,0.0002818638,0.0002066226,0.0001595165,0.00008404667,0.0007994053],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7546227,0.07881348,0.01400573,0.0005788494,0.002132544,0.0004306142,0.0005636303,0.004338639,0.03640481,0.0005648023,0.007185999,0.1003582],"study_design_scores_gemma":[0.6536098,0.3307579,0.009924444,0.00002206737,0.0004352744,0.0002542769,0.00009010793,0.001036463,0.0016941,0.0002258999,0.001914156,0.00003559937],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905493,0.001933062,0.0007659631,0.0009491961,0.0001657156,0.002737154,0.001246804,0.0001005179,0.001552469],"genre_scores_gemma":[0.9814141,0.002458454,0.002998412,0.001833754,0.0002473414,0.004437904,0.003177432,0.00007360257,0.003359045],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003391176,"threshold_uncertainty_score":0.01402509,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02085390900680943,"score_gpt":0.2876598021350212,"score_spread":0.2668058931282117,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}