{"id":"W2010542147","doi":"10.1016/j.ajpath.2013.12.031","title":"Activated Neutrophils Induce Epithelial Cell Apoptosis Through Oxidant-Dependent Tyrosine Dephosphorylation of Caspase-8","year":2014,"lang":"en","type":"article","venue":"American Journal Of Pathology","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"Canadian Institutes of Health Research","keywords":"Dephosphorylation; Cell biology; Apoptosis; Chemistry; Tyrosine phosphorylation; Phosphorylation; NADPH oxidase; LYN; Reactive oxygen species; Proto-oncogene tyrosine-protein kinase Src; Biology; Biochemistry; Phosphatase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003279555,0.0005820775,0.0002369656,0.0003512691,0.0002178633,0.0003400045,0.0002132227,0.0004190509,0.002666726],"category_scores_gemma":[0.000210607,0.0002095655,0.0005073337,0.000166182,0.0002490696,0.0004207007,0.00034321,0.001095899,0.0005233784],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003668441,"about_ca_system_score_gemma":0.000323959,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002509335,"about_ca_topic_score_gemma":0.0004754127,"domain_scores_codex":[0.9996411,0.00007983251,0.00003173807,0.00003535677,0.00008126,0.0001307665],"domain_scores_gemma":[0.9998701,0.00001992593,0.00003427593,0.0000207395,0.00002863506,0.00002630426],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001166496,0.000231503,0.0007375958,0.0001437003,0.00002719078,0.0002467368,0.00005587263,0.00007935046,0.9911198,0.0004392942,0.0002566563,0.005495825],"study_design_scores_gemma":[0.0002429919,0.001098083,0.0166985,0.00003360787,0.00004005935,0.001182706,0.0001313894,0.001523017,0.975454,0.0004070039,0.003179285,0.000009289512],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9850605,0.004756266,0.005996653,0.0004046909,0.0001822701,0.000134554,0.0003748301,0.0001047336,0.002985538],"genre_scores_gemma":[0.9941279,0.001257077,0.001553697,0.0000697563,0.00002163605,0.00005788772,0.0002794374,0.000005730092,0.002626874],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002666726,"threshold_uncertainty_score":0.008921027,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01023135632735288,"score_gpt":0.2298428730959353,"score_spread":0.2196115167685824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}