{"id":"W2010547190","doi":"10.1021/bi602425c","title":"Intrinsic Fluorescence Reports a Global Conformational Change in the N-Lobe of Human Serum Transferrin following Iron Release†","year":2007,"lang":"en","type":"article","venue":"Biochemistry","topic":"Iron Metabolism and Disorders","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute","keywords":"Chemistry; Fluorescence; Reaction rate constant; Transferrin; Mutant; Tryptophan; Conformational change; Absorbance; Biophysics; Kinetics; Biochemistry; Stereochemistry; Crystallography; Chromatography; Biology; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003189557,0.0004403497,0.0003464117,0.0001748852,0.000184657,0.0002364521,0.000376389,0.0004979432,0.001723654],"category_scores_gemma":[0.000509782,0.0001802917,0.0003881636,0.0001790066,0.000369529,0.0003670506,0.0002550789,0.0008707888,0.0004896727],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005278375,"about_ca_system_score_gemma":0.000195012,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008079784,"about_ca_topic_score_gemma":0.0004629574,"domain_scores_codex":[0.999785,0.00002627362,0.000008153249,0.0000684783,0.00006973874,0.00004239286],"domain_scores_gemma":[0.9996518,0.00008727369,0.00007804675,0.00005119294,0.00008690268,0.00004483031],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001153076,0.00001814504,0.000449295,0.00004857045,0.00001022157,0.00008851687,0.00002736662,0.00007640556,0.997456,0.00009730775,0.0001077097,0.00150504],"study_design_scores_gemma":[0.00001526168,0.0002202348,0.008873536,0.00001140815,0.00001461681,0.0005920471,0.00003967457,0.0022884,0.9865803,0.0000846835,0.001263693,0.00001621057],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9676086,0.001502234,0.0267891,0.0002692273,0.00003949145,0.00004549462,0.000554491,0.0003861843,0.002805225],"genre_scores_gemma":[0.9870956,0.0006847946,0.008189609,0.0001537715,0.00001896006,0.00005397933,0.0006483882,0.00005222065,0.003102662],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001723654,"threshold_uncertainty_score":0.005766153,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01538667945593867,"score_gpt":0.2903111456676757,"score_spread":0.2749244662117371,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}