{"id":"W2010551600","doi":"10.1073/pnas.0700825104","title":"A βPix–Pak2a signaling pathway regulates cerebral vascular stability in zebrafish","year":2007,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Zebrafish Biomedical Research Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":125,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Fondation pour la Recherche Médicale; Heart and Stroke Foundation of Canada; Canadian Institutes of Health Research; March of Dimes Foundation","keywords":"Zebrafish; Biology; Guanine nucleotide exchange factor; Cell biology; Gene knockdown; Mutation; Embryonic stem cell; Mutant; Signal transduction; CDC42; Blood–brain barrier; Genetics; Neuroscience; Central nervous system; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004036967,0.0000824975,0.0001153512,0.0001234884,0.0001048291,0.00001550923,0.0007943898,0.0001315473,0.00001660142],"category_scores_gemma":[0.001660946,0.00005985517,0.00008783639,0.0008188542,0.001081299,0.00002412224,0.0001840907,0.0001561344,7.412431e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003137956,"about_ca_system_score_gemma":0.00007838943,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001152962,"about_ca_topic_score_gemma":0.000001166116,"domain_scores_codex":[0.9980126,0.00001032287,0.0003602866,0.0003168297,0.001049197,0.0002507413],"domain_scores_gemma":[0.9993634,0.00008188959,0.000192701,0.00001783444,0.0002734326,0.00007070407],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001605403,0.0000653639,0.009243762,0.00002884978,0.000008886693,4.077492e-9,0.00003704798,0.000008876923,0.9851967,0.004836766,0.0001816886,0.0003760604],"study_design_scores_gemma":[0.00016917,0.0000454934,0.07285969,0.00002878437,0.000002084992,0.000001386838,0.0001217575,0.00008352294,0.9101599,0.0158299,0.0006364136,0.00006190729],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961322,0.0001404475,0.00001472198,0.001293322,0.000006252018,0.0002254323,0.00001286113,0.000004632621,0.002170116],"genre_scores_gemma":[0.9982294,0.00001089792,0.001465746,0.0001740887,0.00007542279,0.00001304219,8.916298e-7,0.000004224377,0.00002626571],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07503676,"threshold_uncertainty_score":0.3984091,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03158644625179649,"score_gpt":0.3122953506773881,"score_spread":0.2807089044255916,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}