{"id":"W2010577059","doi":"10.1038/nature03239","title":"Interaction network containing conserved and essential protein complexes in Escherichia coli","year":2005,"lang":"en","type":"article","venue":"Nature","topic":"Bioinformatics and Genomic Networks","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1208,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada Research Chairs; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Escherichia coli; Conserved sequence; Chemistry; Escherichia coli Proteins; Biology; Microbiology; Genetics; Computational biology; Biochemistry; Peptide sequence; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001752434,0.0002139351,0.0002640598,0.001317277,0.000464017,0.0004726965,0.0003335718,0.0002728241,0.001237352],"category_scores_gemma":[0.001022793,0.0001309803,0.0002097039,0.001602499,0.0002123052,0.000462958,0.0002297578,0.000164571,0.0001678048],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005138242,"about_ca_system_score_gemma":0.0005336773,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004073541,"about_ca_topic_score_gemma":0.005578666,"domain_scores_codex":[0.9998349,0.00003691234,0.0000130311,0.00005246011,0.00003808213,0.00002463013],"domain_scores_gemma":[0.9993427,0.000344244,0.0001217299,0.00004799033,0.00007788827,0.00006538691],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"observational","study_design_scores_codex":[0.004457577,0.0005324284,0.1490125,0.001741004,0.0006248035,0.005814858,0.0005160052,0.3700944,0.2365141,0.1072977,0.01801764,0.105377],"study_design_scores_gemma":[0.000106632,0.0001505292,0.1180222,0.00007803935,0.0004868072,0.002167531,0.0002855617,0.750901,0.04251935,0.06150549,0.02371478,0.00006208704],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9505149,0.001237356,0.03498401,0.0004971598,0.00001807148,0.0000372201,0.008241574,0.000499296,0.003970396],"genre_scores_gemma":[0.981638,0.0004245567,0.01128545,0.00005822504,0.000007149236,0.00002746545,0.005775968,0.00001995048,0.0007632033],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004073541,"threshold_uncertainty_score":0.008099616,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005677413497320298,"score_gpt":0.2421108747591191,"score_spread":0.2364334612617988,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}