{"id":"W2010577903","doi":"10.1371/journal.ppat.0030085","title":"HIV-1 Vpr-Mediated G2 Arrest Involves the DDB1-CUL4AVPRBP E3 Ubiquitin Ligase","year":2007,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":185,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"","keywords":"DDB1; Ubiquitin ligase; Cullin; Biology; Cell biology; Ubiquitin; Small interfering RNA; DNA ligase; Molecular biology; Cell cycle checkpoint; Cell cycle; RNA; Biochemistry; DNA; Cell; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.000523739,0.0002564375,0.0002720161,0.0001262669,0.0004397213,0.00002961225,0.0003603486,0.00022906,0.001004985],"category_scores_gemma":[0.0003815979,0.000166311,0.0001462033,0.000251081,0.0003885313,0.0000607829,0.0001437746,0.0004527326,0.01655306],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007536336,"about_ca_system_score_gemma":0.0001072553,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004871953,"about_ca_topic_score_gemma":0.0001924772,"domain_scores_codex":[0.9980124,0.0002452519,0.0003263949,0.0003830382,0.0001078517,0.0009250903],"domain_scores_gemma":[0.9985217,0.0006287174,0.00008975231,0.0005403972,0.0001047829,0.0001146637],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002447332,0.0008675918,0.02268366,0.00002553343,0.0005640883,0.0005413536,0.001365366,0.000001270838,0.9535967,0.0003867407,0.01547658,0.004246397],"study_design_scores_gemma":[0.003848894,0.0007148344,0.07165939,0.0001001126,0.0002355642,0.0001269489,0.002260813,0.00001027868,0.7173695,0.0001912908,0.2028577,0.0006247055],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884992,0.002941175,0.00005022829,0.001264621,0.000303191,0.000554495,0.0008744639,0.00016699,0.005345694],"genre_scores_gemma":[0.9941723,0.0002289022,0.00007681225,0.0004159817,0.0001385709,0.000080887,0.001253914,0.00003297944,0.003599676],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2362272,"threshold_uncertainty_score":0.9999082,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0221488951449244,"score_gpt":0.2518728585103396,"score_spread":0.2297239633654152,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}