{"id":"W2010598858","doi":"10.1016/j.antiviral.2010.03.010","title":"Dengue virus replicons: Production of an interserotypic chimera and cell lines from different species, and establishment of a cell-based fluorescent assay to screen inhibitors, validated by the evaluation of ribavirin's activity","year":2010,"lang":"en","type":"article","venue":"Antiviral Research","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Infection and Immunity","funders":"Agence Nationale de la Recherche","keywords":"Replicon; Dengue virus; Virology; Dengue fever; Biology; Flavivirus; Subgenomic mRNA; Green fluorescent protein; Ribavirin; Virus; Molecular biology; Hepatitis C virus; Gene; RNA; Genetics; Plasmid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002185186,0.0001413732,0.0003227172,0.000159757,0.00007745437,0.00003404338,0.0001300308,0.00007856985,0.00002859077],"category_scores_gemma":[0.0006375911,0.00009596472,0.00005585488,0.0002217945,0.0002652086,0.0001119094,0.0001245654,0.0003375442,7.08632e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003467048,"about_ca_system_score_gemma":0.0001674275,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00334297,"about_ca_topic_score_gemma":0.0005911459,"domain_scores_codex":[0.9973971,0.0006252757,0.0003052043,0.0004206334,0.001032979,0.0002188258],"domain_scores_gemma":[0.9983151,0.0002054988,0.0001465997,0.0005942968,0.000629114,0.0001094089],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001278377,0.001052835,0.01913637,0.0001052095,0.00003525832,8.561191e-7,0.0001765122,0.000001300908,0.9504697,0.000006667345,0.0005529406,0.02718398],"study_design_scores_gemma":[0.001374335,0.0005498035,0.2265314,0.0001013846,0.0001210723,2.685391e-7,0.0002016217,0.002179062,0.7688095,0.00002088571,0.00004925899,0.00006144499],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997112,0.0003244009,0.0000308613,0.0006621009,0.00008559927,0.001573669,0.0001489392,0.00000764395,0.0000547813],"genre_scores_gemma":[0.9994912,0.00006286683,0.00006788431,0.0000162934,0.0001227565,0.00005444915,0.0001032175,0.00001510758,0.00006623301],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.207395,"threshold_uncertainty_score":0.5053593,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04848538936427187,"score_gpt":0.3572641395959428,"score_spread":0.3087787502316709,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}