{"id":"W2010603109","doi":"10.1371/journal.ppat.1003539","title":"SIGIRR, a Negative Regulator of TLR/IL-1R Signalling Promotes Microbiota Dependent Resistance to Colonization by Enteric Bacterial Pathogens","year":2013,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; Okanagan University College; University of British Columbia, Okanagan Campus; University of British Columbia; BC Children's Hospital","funders":"National Institutes of Health; Canadian Institutes of Health Research; CH.I.L.D. Foundation; Child and Family Research Institute; Crohn's and Colitis Foundation of Canada; University of British Columbia; Canadian Association of Gastroenterology; Crohn's and Colitis Foundation","keywords":"Citrobacter rodentium; Biology; Innate immune system; Microbiology; Colonisation resistance; Pathogen; Salmonella; Immunology; Immune system; Bacteria; Colonization","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000167531,0.0004763208,0.0003030011,0.000274332,0.0001263077,0.0003822294,0.000226128,0.0004111132,0.001305511],"category_scores_gemma":[0.0001643529,0.0002050536,0.0003001083,0.0001130195,0.0003551778,0.0001714128,0.0002581824,0.001086477,0.0004812236],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001273896,"about_ca_system_score_gemma":0.0001692056,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000178544,"about_ca_topic_score_gemma":0.0003086128,"domain_scores_codex":[0.9997777,0.00004266893,0.0000190042,0.00004927527,0.0000497408,0.00006173176],"domain_scores_gemma":[0.9997585,0.00001874812,0.00008428207,0.00002228738,0.00001969073,0.00009650225],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002380391,0.00003691658,0.0004040102,0.00003347633,0.000003317803,0.0000951851,0.00001104303,0.00003152377,0.9980586,0.000043965,0.00006625519,0.0009776558],"study_design_scores_gemma":[0.00009787635,0.002291831,0.05402037,0.00003902132,0.00007333641,0.00189716,0.000183052,0.001760411,0.9343892,0.0001911183,0.005034482,0.00002218668],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944694,0.001887024,0.001442113,0.00017853,0.00005154305,0.00001837859,0.0002802506,0.0002040483,0.001468625],"genre_scores_gemma":[0.9932422,0.001099971,0.001256391,0.00009973767,0.00002452793,0.00003024887,0.0003790443,0.00003874789,0.00382917],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001305511,"threshold_uncertainty_score":0.004367411,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008037445887869012,"score_gpt":0.196722327335376,"score_spread":0.188684881447507,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}