{"id":"W2010613696","doi":"10.1016/j.clinthera.2013.07.012","title":"Oc013 — A Simplified Method For Busulfan Therapeutic Drug Monitoring Using Dried Blood Spot Sampling In Pediatric Patient Undergoing Stem Cell Transplantation","year":2013,"lang":"en","type":"article","venue":"Clinical Therapeutics","topic":"Blood disorders and treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Medicine; Busulfan; Therapeutic drug monitoring; Dried blood spot; Hematopoietic stem cell transplantation; Pharmacokinetics; Therapeutic window; Stem cell; Hematopoietic stem cell; Therapeutic index; Blood sampling; Drug; Transplantation; Therapeutic effect; Pharmacology; Haematopoiesis; Surgery; Internal medicine; Chromatography","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003270451,0.0002565314,0.0003084645,0.00006261797,0.0001236005,0.00005966011,0.0001669377,0.0002583641,0.000003115793],"category_scores_gemma":[0.00001120762,0.0002419362,0.0002175029,0.0001451694,0.00003175154,0.00001254765,0.00003563987,0.0001722918,0.000002847776],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001759583,"about_ca_system_score_gemma":0.0001003907,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002912121,"about_ca_topic_score_gemma":0.00001974535,"domain_scores_codex":[0.9980624,0.0002029796,0.0006902996,0.0005106212,0.0001341722,0.0003994681],"domain_scores_gemma":[0.998863,0.000419319,0.0002239926,0.000300472,0.00009552111,0.00009762462],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006428605,0.002915217,0.5921516,0.0004264465,0.0008025444,0.000008373043,0.001245895,0.003801004,0.1182974,0.00009388093,0.00001053342,0.2796043],"study_design_scores_gemma":[0.03996043,0.00542012,0.2005731,0.0003029049,0.005644643,0.0000424686,0.004899151,0.01654555,0.7127576,0.008645807,0.001580125,0.003628073],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9592351,0.002386278,0.03712672,0.00005951487,0.0003203508,0.0007865449,0.00001139379,0.00002010921,0.00005404615],"genre_scores_gemma":[0.9733346,0.002846322,0.02301991,0.0003257969,0.0002498929,0.00008186002,0.00004231693,0.00005817376,0.00004111089],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5944602,"threshold_uncertainty_score":0.9865872,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0800214425348415,"score_gpt":0.369161085063021,"score_spread":0.2891396425281795,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}