{"id":"W2010624323","doi":"10.1056/nejmoa1214271","title":"ERCC1 Isoform Expression and DNA Repair in Non–Small-Cell Lung Cancer","year":2013,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":363,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; Princess Margaret Cancer Centre; University Health Network","funders":"National Cancer Institute","keywords":"ERCC1; Medicine; Cisplatin; Lung cancer; DNA repair; Biomarker; Oncology; Chemotherapy; Nucleotide excision repair; Cancer research; Internal medicine; DNA; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003959211,0.0001160758,0.000214868,0.0000777013,0.00002106532,0.00000503052,0.0001062819,0.00009755698,0.000116016],"category_scores_gemma":[0.00008715245,0.00007699425,0.00004262752,0.00005101982,0.00003110819,0.00000861735,0.00004949686,0.0001612732,9.388894e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001723252,"about_ca_system_score_gemma":0.00007641293,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001994008,"about_ca_topic_score_gemma":0.00008602972,"domain_scores_codex":[0.9991868,0.00004041748,0.0003148521,0.0001391632,0.0001532573,0.0001654934],"domain_scores_gemma":[0.9994015,0.00002075163,0.0001668301,0.0001397406,0.00008760198,0.0001836421],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001037143,0.00002399958,0.007795068,0.00003856832,0.00001927342,0.00002433768,0.0003262736,0.00001327349,0.9603801,0.000002171208,0.01832946,0.01294375],"study_design_scores_gemma":[0.05547259,0.002971631,0.03249108,0.001299598,0.0001475841,0.0005920953,0.0006928516,0.0009115215,0.8549858,0.0004191498,0.04960024,0.0004158255],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931692,0.004416513,0.0004462801,0.0009826921,0.0003018461,0.0001426682,0.000001005536,0.000004489598,0.0005352623],"genre_scores_gemma":[0.9939496,0.001521337,0.001382061,0.0004582063,0.001642444,0.000005293637,0.000003157716,0.00001491432,0.001023016],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1053943,"threshold_uncertainty_score":0.3139734,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006561960301400329,"score_gpt":0.243644781292809,"score_spread":0.2370828209914086,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}