{"id":"W2010646007","doi":"10.5966/sctm.2014-0011","title":"Selection Based on FOXA2 Expression Is Not Sufficient to Enrich for Dopamine Neurons From Human Pluripotent Stem Cells","year":2014,"lang":"en","type":"article","venue":"Stem Cells Translational Medicine","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Stemcell Technologies","funders":"Medicinska Forskningsrådet; Karolinska Institutet; Consejo Nacional de Ciencia y Tecnología; National Institute of Neurological Disorders and Stroke; Medical Research Council; Harvard Stem Cell Institute; Eusko Jaurlaritza","keywords":"Induced pluripotent stem cell; FOXA2; Biology; Embryonic stem cell; Cell biology; Stem cell; Progenitor cell; Cellular differentiation; Neural stem cell; Dopamine; Neuroscience; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000574271,0.0003572481,0.0003560038,0.0002208783,0.0002648281,0.00002243097,0.0003259749,0.0002043444,0.0001565027],"category_scores_gemma":[0.00001335383,0.0003071472,0.000157293,0.0002237012,0.00009733115,0.000007134133,0.00003887848,0.0001895943,0.00004256588],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004502893,"about_ca_system_score_gemma":0.00007870691,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003776,"about_ca_topic_score_gemma":0.00002449144,"domain_scores_codex":[0.9968706,0.0002000449,0.0005703153,0.0009437473,0.0009216501,0.0004935995],"domain_scores_gemma":[0.9985325,0.0002550425,0.0001427913,0.0004770821,0.0002613083,0.0003313232],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005827972,0.0001997328,0.000131914,0.00008063931,0.00002659065,0.000001566442,0.000126196,0.01257079,0.979421,0.00002579935,0.004784635,0.00204834],"study_design_scores_gemma":[0.002710802,0.002140845,0.0007331735,0.0001358841,0.00004374568,0.00000118925,0.00004455992,0.01999006,0.9159152,0.00001685696,0.05796828,0.0002994442],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7919096,0.0001582719,0.198896,0.00482548,0.000781022,0.002000209,0.0004275471,0.00005780331,0.0009441195],"genre_scores_gemma":[0.9937922,0.00001552858,0.001072012,0.00149467,0.000824448,0.0001369224,0.0004466606,0.00006625072,0.002151289],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2018827,"threshold_uncertainty_score":0.9999381,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0238561629634031,"score_gpt":0.277310433362663,"score_spread":0.2534542703992599,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}