{"id":"W2010680056","doi":"10.1016/j.actatropica.2012.08.020","title":"Towards the establishment of a consensus real-time qPCR to monitor Trypanosoma cruzi parasitemia in patients with chronic Chagas disease cardiomyopathy: A substudy from the BENEFIT trial","year":2012,"lang":"en","type":"article","venue":"Acta Tropica","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":163,"is_retracted":false,"has_abstract":true,"ca_institutions":"Population Health Research Institute; McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Benznidazole; Chagas disease; Trypanosoma cruzi; Parasitemia; Biology; TaqMan; Nifurtimox; Real-time polymerase chain reaction; DNA extraction; Primer (cosmetics); Virology; Polymerase chain reaction; Immunology; Genetics; Parasite hosting; Malaria; Plasmodium falciparum; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.04619975,0.0007823816,0.002603802,0.0004492052,0.0008872515,0.001673236,0.0007273434,0.002080804,0.001889467],"category_scores_gemma":[0.01779072,0.0004701694,0.001802984,0.0007693032,0.000682891,0.001421815,0.001129163,0.002372765,0.0005942216],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008327628,"about_ca_system_score_gemma":0.001767258,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001011876,"about_ca_topic_score_gemma":0.002527558,"domain_scores_codex":[0.9826561,0.01289925,0.001521733,0.0008366111,0.001463064,0.0006231311],"domain_scores_gemma":[0.9879822,0.004069053,0.002036148,0.001621277,0.003499367,0.0007920142],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.2991191,0.006283059,0.1633392,0.01389892,0.009005214,0.0003973489,0.002408852,0.00249596,0.05078305,0.004552173,0.02913882,0.4185784],"study_design_scores_gemma":[0.2032224,0.1710691,0.3470426,0.007864406,0.02741311,0.001157165,0.001349898,0.004950098,0.01935565,0.004494041,0.2117182,0.0003634582],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7099586,0.1371095,0.04888491,0.01822857,0.005664724,0.04054808,0.0145317,0.0003683938,0.02470561],"genre_scores_gemma":[0.8323857,0.01710465,0.05789989,0.01451818,0.002506117,0.05933492,0.01310281,0.0001559887,0.002991828],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04619975,"threshold_uncertainty_score":0.2443306,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01951631336340171,"score_gpt":0.2778904688445714,"score_spread":0.2583741554811697,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}