{"id":"W2010689685","doi":"10.1111/j.1600-0854.2007.00562.x","title":"The Cellular Trafficking of the Secretory Proprotein Convertase PCSK9 and Its Dependence on the LDLR","year":2007,"lang":"en","type":"article","venue":"Traffic","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":243,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital; Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research; National Institute on Aging; National Institutes of Health; National Heart, Lung, and Blood Institute; Fonds Québécois de la Recherche sur la Nature et les Technologies; University of Wisconsin-Madison","keywords":"PCSK9; LDL receptor; Endosome; Proprotein convertase; Biology; Cell biology; Endoplasmic reticulum; Golgi apparatus; Kexin; Biochemistry; Cholesterol; Lipoprotein","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006415745,0.000123566,0.00008190325,0.00001263637,0.00025574,0.00001570961,0.0002588075,0.0001076061,0.00001261424],"category_scores_gemma":[0.00003803422,0.00006235292,0.00008761373,0.00006355667,0.0001682265,0.000002346504,0.00002655752,0.0001581321,0.000003342888],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007138541,"about_ca_system_score_gemma":0.00004623652,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004731153,"about_ca_topic_score_gemma":0.000153519,"domain_scores_codex":[0.9991404,0.00006407728,0.0001881712,0.000204145,0.0001964959,0.0002066629],"domain_scores_gemma":[0.9994636,0.00004566895,0.00008541143,0.0003197277,0.00004426181,0.00004140158],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001659772,0.00003437037,0.0001731775,0.00002249477,0.00002584731,0.000004466153,0.0003258192,0.0001696596,0.9944388,0.0007196681,0.00003068512,0.003889088],"study_design_scores_gemma":[0.0003014847,0.0001459466,0.002155666,0.0000303003,0.00002551056,0.000006644241,0.0002995227,0.0007010701,0.9819875,0.00001350088,0.01420728,0.0001256193],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964406,0.002051087,0.0004372364,0.0003297479,0.0001193093,0.0004180015,0.000004653052,0.000009265952,0.0001900723],"genre_scores_gemma":[0.9993391,0.0001006558,0.000007028922,0.000100891,0.00008249909,0.000009059731,0.00003836382,0.0000138779,0.0003085291],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0141766,"threshold_uncertainty_score":0.2542678,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009798230066158398,"score_gpt":0.2056611921513603,"score_spread":0.1958629620852018,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}