{"id":"W2010711123","doi":"10.1016/j.ccr.2013.04.011","title":"EZH2 Is Required for Germinal Center Formation and Somatic EZH2 Mutations Promote Lymphoid Transformation","year":2013,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":841,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency","funders":"National Cancer Institute","keywords":"EZH2; Germinal center; Histone methyltransferase; Biology; Somatic cell; Somatic hypermutation; B cell; Chromatin; Cancer research; Gene silencing; Histone; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001437766,0.0002903618,0.0002218733,0.0003256022,0.0002665381,0.0004773801,0.000257847,0.0002997072,0.002483607],"category_scores_gemma":[0.0001988761,0.0002858718,0.0002003461,0.0002011992,0.0003387636,0.0002569974,0.0005099698,0.0006413485,0.0006427826],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004466201,"about_ca_system_score_gemma":0.0001993363,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006566319,"about_ca_topic_score_gemma":0.001738053,"domain_scores_codex":[0.9998164,0.00002330088,0.00001669207,0.00002715625,0.00005632688,0.00006012422],"domain_scores_gemma":[0.9998409,0.00002928471,0.00003920316,0.00002648329,0.00001188616,0.00005226876],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001419287,0.00001436241,0.0004876184,0.000008624941,0.000004989638,0.0001056742,0.000006665906,0.00005896011,0.998384,0.0002421966,0.00005575554,0.0004891097],"study_design_scores_gemma":[0.00001955588,0.00004033947,0.00843659,0.000001352422,0.00001093825,0.0004575634,0.00002970814,0.0006087192,0.9882442,0.0001012374,0.002046729,0.000003029046],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940811,0.0008292426,0.002333847,0.0001575054,0.00003421327,0.00001103611,0.0002792354,0.0001578008,0.002116042],"genre_scores_gemma":[0.9971842,0.0001287445,0.0004881603,0.00002790407,0.000006658022,0.00000728126,0.0002543806,0.00003006699,0.001872658],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002483607,"threshold_uncertainty_score":0.00830847,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01273970078456645,"score_gpt":0.2634424101023659,"score_spread":0.2507027093177994,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}