{"id":"W2010738219","doi":"10.1371/journal.pone.0041354","title":"Differential Regulation of Transcription Factors by Location-Specific EGF Receptor Signaling via a Spatio-Temporal Interplay of ERK Activation","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Internalization; MAPK/ERK pathway; Cell biology; Endocytosis; Endosome; Chinese hamster ovary cell; Epidermal growth factor receptor; Signal transduction; Cell growth; Cell; Chemistry; Transcription factor; Biology; Phosphorylation; Cell culture; Receptor; Intracellular; Biochemistry; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001137647,0.0001238804,0.0001868059,0.00005739704,0.0000400067,0.000008178683,0.00007923682,0.00014557,0.0004916835],"category_scores_gemma":[0.0000219461,0.0001221137,0.00006837022,0.00009396714,0.00003001873,0.0000225528,0.00001387459,0.00005925083,0.000002120271],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000222218,"about_ca_system_score_gemma":0.000014232,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002687408,"about_ca_topic_score_gemma":0.000002168353,"domain_scores_codex":[0.9990507,0.00006399352,0.0003422879,0.0001669333,0.0002328331,0.000143287],"domain_scores_gemma":[0.9993559,0.00001298731,0.0002538228,0.0001532744,0.0001726818,0.00005133868],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001476378,0.0005748722,0.004078621,0.00007718906,0.00009711884,3.519889e-9,0.0003845558,0.0000235859,0.9940543,0.00005794052,0.00008014222,0.0004240856],"study_design_scores_gemma":[0.0002705838,0.0001956217,0.001186764,0.0001085428,0.0000341467,8.182237e-8,0.00009586337,0.0001890125,0.9976354,0.00002955242,0.0001340181,0.0001203822],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8744652,0.0001688019,0.1250369,0.00001249168,0.00009138914,0.0001809434,0.00002020397,0.000007954153,0.00001608204],"genre_scores_gemma":[0.9962252,0.00003614022,0.001988828,0.000005396874,0.0001879225,0.00001175153,0.00145069,0.00002096431,0.00007306025],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1230481,"threshold_uncertainty_score":0.538359,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02278670358087217,"score_gpt":0.2203831607096278,"score_spread":0.1975964571287556,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}