{"id":"W2010746038","doi":"10.1073/pnas.1305464110","title":"Metalloproteases meprin α and meprin β are C- and N-procollagen proteinases important for collagen assembly and tensile strength","year":2013,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":140,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Procollagen peptidase; Type I collagen; Connective tissue; Collagen, type I, alpha 1; Chemistry; Metalloproteinase; Fibril; Extracellular matrix; Matrix metalloproteinase; Biochemistry; Cell biology; Protein precursor; Molecular biology; Biology; Enzyme; Endocrinology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001542557,0.000437205,0.0002213746,0.0002614123,0.0001319407,0.0003065083,0.0001262846,0.000239492,0.0009681406],"category_scores_gemma":[0.0001642959,0.0001362581,0.000213333,0.00009606989,0.0001684003,0.0002310617,0.0002255548,0.0003752547,0.0004475972],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001903716,"about_ca_system_score_gemma":0.00009493752,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002537271,"about_ca_topic_score_gemma":0.000229767,"domain_scores_codex":[0.9998877,0.00001660227,0.00001445365,0.00002973984,0.0000320686,0.00001947232],"domain_scores_gemma":[0.9998628,0.0000156041,0.00005978577,0.000008656205,0.00001594848,0.00003714861],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000104084,0.000008416069,0.0006465042,0.0000424368,0.00000872943,0.000178917,0.00001098292,0.00003424418,0.995111,0.0001243622,0.0000502184,0.003680011],"study_design_scores_gemma":[0.00001722968,0.0001709969,0.02684929,0.00001346934,0.00002756038,0.003154719,0.00003676784,0.0006150967,0.9611965,0.0001281074,0.007782773,0.00000744421],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9738092,0.01122695,0.01112085,0.0002269799,0.0000478705,0.00005357081,0.0009632439,0.000119861,0.002431423],"genre_scores_gemma":[0.9778515,0.005834325,0.008694859,0.00007439221,0.00002570933,0.0000530841,0.001073768,0.00001605547,0.006376279],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009681406,"threshold_uncertainty_score":0.003238738,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02349145727118611,"score_gpt":0.2722296641706247,"score_spread":0.2487382068994386,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}