{"id":"W2010766452","doi":"10.1021/bi051251t","title":"Calmodulin Regulation and Identification of Calmodulin Binding Region of Type-3 Ryanodine Receptor Calcium Release Channel","year":2005,"lang":"en","type":"article","venue":"Biochemistry","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Heart, Lung, and Blood Institute","keywords":"Ryanodine receptor; Calmodulin; Gene isoform; Biochemistry; RYR1; Chemistry; Glutathione; Cysteine; Intracellular; Receptor; Cell biology; Biology; Biophysics; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001044737,0.0001773245,0.0002712663,0.0001364885,0.0001190078,0.0001746557,0.0002274622,0.0003637118,0.0009071905],"category_scores_gemma":[0.0001816289,0.00008583229,0.0003145138,0.0001235146,0.0001443644,0.0001598926,0.0001527657,0.000427447,0.0003923817],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000209118,"about_ca_system_score_gemma":0.0001253098,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009393811,"about_ca_topic_score_gemma":0.001210582,"domain_scores_codex":[0.9999118,0.00001282846,0.000007301106,0.00002885282,0.00002381573,0.00001535539],"domain_scores_gemma":[0.9999112,0.0000133389,0.00002934503,0.000008572244,0.00001975088,0.00001778463],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006397266,0.000007042797,0.0003039159,0.00003166215,0.000002566394,0.00006978609,0.00001105509,0.00001261591,0.9985689,0.00005851201,0.00003862712,0.0008314318],"study_design_scores_gemma":[0.00006351335,0.0002143903,0.0730782,0.00002706151,0.00004379896,0.001467759,0.00006299411,0.002115004,0.9143606,0.0002474909,0.008304111,0.00001508888],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9794897,0.009982236,0.007542942,0.0002860571,0.00008851592,0.00006550356,0.0006852617,0.00006201268,0.001797918],"genre_scores_gemma":[0.9848172,0.002835345,0.008426709,0.0002701515,0.000051693,0.00005119586,0.00141777,0.00002526654,0.002104583],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009393811,"threshold_uncertainty_score":0.00303483,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01784065518677927,"score_gpt":0.250798331659272,"score_spread":0.2329576764724927,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}