{"id":"W2010766452","doi":"10.1021/bi051251t","title":"Calmodulin Regulation and Identification of Calmodulin Binding Region of Type-3 Ryanodine Receptor Calcium Release Channel","year":2005,"lang":"en","type":"article","venue":"Biochemistry","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Heart, Lung, and Blood Institute","keywords":"Ryanodine receptor; Calmodulin; Gene isoform; Biochemistry; RYR1; Chemistry; Glutathione; Cysteine; Intracellular; Receptor; Cell biology; Biology; Biophysics; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001662361,0.0001235129,0.0001370902,0.00005618301,0.00004639695,0.000007058786,0.00007475026,0.0002340768,0.00002386576],"category_scores_gemma":[0.0001550585,0.000130767,0.00005645296,0.0001428859,0.0000934288,0.000008626737,0.00004085403,0.00005314658,0.000005294591],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002708969,"about_ca_system_score_gemma":0.00004364601,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008460594,"about_ca_topic_score_gemma":8.210598e-7,"domain_scores_codex":[0.9990373,0.00002635504,0.0003844953,0.000295154,0.0001384689,0.0001182901],"domain_scores_gemma":[0.9991317,0.000007657913,0.0002850503,0.0002753927,0.0002338593,0.00006636303],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001840495,0.00005741227,0.0002520668,0.00008463235,0.0000167149,1.605922e-7,0.0000377487,0.0003650453,0.9948435,0.0000214047,0.002079079,0.002058114],"study_design_scores_gemma":[0.0004145259,0.00006711833,0.0007468632,0.00003307418,0.00001564988,0.00001306857,0.00006726879,0.005150514,0.9913999,0.00001382552,0.001950139,0.0001280266],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952672,0.0004117572,0.003561288,0.0002500481,0.0002004063,0.0001182137,0.00002553341,0.00001249838,0.0001530877],"genre_scores_gemma":[0.9952204,0.0001164943,0.0002875687,0.00001901286,0.0005088123,0.00000635368,0.0005397636,0.00001674921,0.003284897],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004785469,"threshold_uncertainty_score":0.5332522,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01784065518677927,"score_gpt":0.250798331659272,"score_spread":0.2329576764724927,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}