{"id":"W2010812762","doi":"10.1074/jbc.m112.445841","title":"Identifying Natural Substrates for Dipeptidyl Peptidases 8 and 9 Using Terminal Amine Isotopic Labeling of Substrates (TAILS) Reveals in Vivo Roles in Cellular Homeostasis and Energy Metabolism","year":2013,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Biology; Biochemistry; Dipeptidyl peptidase; In vivo; Kinase; Cell biology; Enzyme; Chemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002692112,0.0001631225,0.0006142549,0.0001391736,0.00003219831,0.00003598348,0.00006455129,0.0001512749,0.00008754188],"category_scores_gemma":[0.0002006017,0.000114597,0.0001316718,0.0001682302,0.0001423951,0.0001403241,0.00003085074,0.0002143378,8.344038e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002782324,"about_ca_system_score_gemma":0.00002592223,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005019769,"about_ca_topic_score_gemma":0.000009514296,"domain_scores_codex":[0.9987356,0.00003578707,0.0007076589,0.0001820436,0.0001298459,0.0002090551],"domain_scores_gemma":[0.9991392,0.0001589636,0.0003584024,0.00007032125,0.0001593028,0.0001138009],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007350001,0.000094743,0.04025874,0.0002043175,0.00003793758,0.000060142,0.00004565509,0.000004527553,0.9582928,0.000006264424,0.00000615842,0.0009152344],"study_design_scores_gemma":[0.001456226,0.00006930048,0.03213081,0.001056657,0.00007546032,0.0002197697,0.001159826,0.0005529113,0.9626686,0.0004622183,0.000009652156,0.0001385736],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926862,0.007069509,0.00002893788,0.0001169019,0.000009030273,0.00005647345,0.00001206649,0.000004123588,0.0000167825],"genre_scores_gemma":[0.9974346,0.0006363882,0.001694538,0.00005108355,0.0001151253,0.000004665396,0.00001000523,0.000006733455,0.00004688308],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008127923,"threshold_uncertainty_score":0.4673131,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02922527653744256,"score_gpt":0.2789569582675832,"score_spread":0.2497316817301406,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}