{"id":"W2010870296","doi":"10.1089/08892220151126508","title":"Safe Use of the CXCR4 Inhibitor ALX40-4C in Humans","year":2001,"lang":"en","type":"article","venue":"AIDS Research and Human Retroviruses","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":108,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; GlaxoSmithKline (Canada); University of Manitoba; University of Ottawa","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"CXCR4; Chemokine receptor; CXCR4 antagonist; Chemokine; Human immunodeficiency virus (HIV); Biology; Extracellular; Receptor; Immunology; Drug; Virus; CXC chemokine receptors; Viral load; Virology; Medicine; Internal medicine; Pharmacology; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009543474,0.000281558,0.0004915037,0.0002478614,0.0004448523,0.0005330436,0.0003559393,0.0008937143,0.004773924],"category_scores_gemma":[0.001208932,0.0001625609,0.0003376334,0.0001224679,0.0005180042,0.0002755714,0.0005004351,0.0006704722,0.002735028],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001718048,"about_ca_system_score_gemma":0.0004503986,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001820886,"about_ca_topic_score_gemma":0.0001896885,"domain_scores_codex":[0.999443,0.0002797193,0.00002636373,0.00006783535,0.0001291806,0.00005393584],"domain_scores_gemma":[0.999568,0.0001073687,0.0000674197,0.0001544127,0.0000380322,0.00006467311],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.007604783,0.002507702,0.01284713,0.0005633594,0.0002493202,0.003601787,0.000373961,0.0007301517,0.1177919,0.008488778,0.02844313,0.816798],"study_design_scores_gemma":[0.003039467,0.04900721,0.03459314,0.0007132927,0.0003077578,0.02763931,0.0003324905,0.002364694,0.1605729,0.01167703,0.7096679,0.00008479811],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6249409,0.07185747,0.135446,0.009690536,0.002107191,0.002017686,0.001622622,0.0034117,0.148906],"genre_scores_gemma":[0.9537169,0.008311003,0.01576679,0.004158608,0.0007805251,0.0005132221,0.0006445473,0.0001212495,0.01598707],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004773924,"threshold_uncertainty_score":0.01597035,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1107833058083901,"score_gpt":0.3622443731929799,"score_spread":0.2514610673845898,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}