{"id":"W2010870296","doi":"10.1089/08892220151126508","title":"Safe Use of the CXCR4 Inhibitor ALX40-4C in Humans","year":2001,"lang":"en","type":"article","venue":"AIDS Research and Human Retroviruses","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":108,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; GlaxoSmithKline (Canada); University of Manitoba; University of Ottawa","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"CXCR4; Chemokine receptor; CXCR4 antagonist; Chemokine; Human immunodeficiency virus (HIV); Biology; Extracellular; Receptor; Immunology; Drug; Virus; CXC chemokine receptors; Viral load; Virology; Medicine; Internal medicine; Pharmacology; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006883161,0.0001463761,0.0002606059,0.0003939207,0.0005193143,0.00005686604,0.0003264478,0.0001550386,0.000796197],"category_scores_gemma":[0.000358806,0.00009606312,0.00007490714,0.000439791,0.001291949,0.000176195,0.0003410042,0.0006775077,0.0003055566],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008448119,"about_ca_system_score_gemma":0.0001092051,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002866259,"about_ca_topic_score_gemma":0.002700377,"domain_scores_codex":[0.9977956,0.0005976462,0.0002954296,0.0003327914,0.0001914781,0.0007870102],"domain_scores_gemma":[0.9987777,0.0004611247,0.00004712351,0.0004917955,0.0001542825,0.00006798034],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002306596,0.000426077,0.9123332,0.00002283999,0.0000888819,0.00003600552,0.000330816,4.302667e-7,0.07249551,0.004948618,0.006447901,0.002639088],"study_design_scores_gemma":[0.001832673,0.001630116,0.8471158,0.00008714278,0.000007919833,0.00001261847,0.0002725402,7.636589e-8,0.02394264,0.00102925,0.1239458,0.0001234012],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947597,0.0013756,0.000001466719,0.0001667191,0.00006008428,0.000405182,0.00007006442,0.00001560821,0.003145623],"genre_scores_gemma":[0.9855664,0.0005261895,0.00002090918,0.00004084497,0.00003406077,0.00004514361,0.00003147962,0.00001514567,0.01371976],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1174979,"threshold_uncertainty_score":0.8717799,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1107833058083901,"score_gpt":0.3622443731929799,"score_spread":0.2514610673845898,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}