{"id":"W2010881438","doi":"10.1182/blood-2005-09-3613","title":"Impaired class switch recombination (CSR) in Waldenstrom macroglobulinemia (WM) despite apparently normal CSR machinery","year":2005,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Immunoglobulin class switching; Biology; Waldenstrom macroglobulinemia; Cytidine deaminase; B cell; Isotype; Molecular biology; Macroglobulinemia; Somatic hypermutation; Monoclonal gammopathy of undetermined significance; Immunology; Antibody; Monoclonal; Monoclonal antibody; Multiple myeloma; Lymphoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001735339,0.0002041973,0.000145117,0.0004732557,0.0001110859,0.0002336142,0.0001146021,0.0002423208,0.0005577501],"category_scores_gemma":[0.0004319336,0.000126987,0.000069131,0.0002196047,0.0002151955,0.0001475257,0.0001749259,0.0001984323,0.0001439367],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001453615,"about_ca_system_score_gemma":0.00009105437,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004438852,"about_ca_topic_score_gemma":0.0004791118,"domain_scores_codex":[0.9998728,0.0000340222,0.000016626,0.00001746556,0.00002580939,0.00003324479],"domain_scores_gemma":[0.9998485,0.00003338065,0.00004743582,0.00001791496,0.000008174571,0.00004458262],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001598833,0.0001424655,0.09244583,0.00008865273,0.00004075193,0.004164166,0.000152149,0.00036358,0.8826553,0.000735968,0.0003385354,0.01727381],"study_design_scores_gemma":[0.0001987369,0.002350261,0.7989047,0.0000333933,0.0001289582,0.04507402,0.000270292,0.003120424,0.1448215,0.001260985,0.003817477,0.00001934577],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993184,0.000300065,0.0001090101,0.00001208657,0.00000160116,0.000002302404,0.00001941446,0.00000945041,0.0002277406],"genre_scores_gemma":[0.9995683,0.0001283416,0.00009700155,0.0000115855,0.000005467382,0.000003076494,0.00005647468,0.000002082778,0.000127673],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005577501,"threshold_uncertainty_score":0.001865864,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01360092421285796,"score_gpt":0.2771064862843348,"score_spread":0.2635055620714768,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}