{"id":"W2010894264","doi":"10.1242/dev.099796","title":"Novel cardiovascular gene functions revealed via systematic phenotype prediction in zebrafish","year":2013,"lang":"en","type":"article","venue":"Development","topic":"Congenital heart defects research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Toronto","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; Harvard Stem Cell Institute; University of California, San Francisco; University of Toronto; Howard Hughes Medical Institute; Williams College; Fondation Leducq; National Heart, Lung, and Blood Institute; National Human Genome Research Institute; Canada Excellence Research Chairs, Government of Canada; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Institutes of Health; National Science Foundation","keywords":"Biology; Zebrafish; Phenotype; Morpholino; Gene knockdown; Computational biology; Gene; Genetics; Loss function; Genetic screen; Model organism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003517577,0.0001325492,0.0002111226,0.00009771007,0.00007038956,0.00003077768,0.00011948,0.0001090042,0.00007952256],"category_scores_gemma":[0.00008586934,0.000125762,0.00009557087,0.0001911851,0.00002197819,0.000007111136,0.0001211486,0.00009269859,0.0005571833],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009132788,"about_ca_system_score_gemma":0.0001365892,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007942659,"about_ca_topic_score_gemma":0.00009127147,"domain_scores_codex":[0.9987292,0.0000694442,0.0003103908,0.0003263017,0.000284379,0.0002803303],"domain_scores_gemma":[0.9993312,0.00001162506,0.00002920692,0.0003863055,0.0001483126,0.00009336822],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00002860794,0.0002052434,0.003550315,0.002066256,0.000670534,0.000007950461,0.0002211365,0.0002246775,0.9850972,0.000003726245,0.001816101,0.006108241],"study_design_scores_gemma":[0.005247843,0.0004531949,0.6981856,0.001388062,0.0001994913,0.0003394704,0.0004448973,0.002690074,0.2453133,0.00005635972,0.04407624,0.001605458],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9791453,0.001317602,0.01684567,0.00003335097,0.000203546,0.001321193,0.000006335229,0.00002435107,0.001102657],"genre_scores_gemma":[0.9942285,0.00001293987,0.002236779,0.00004849808,0.000083406,0.0004942782,0.0001314479,0.00002273794,0.002741383],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7397839,"threshold_uncertainty_score":0.7161651,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0126252677226724,"score_gpt":0.2182599964623876,"score_spread":0.2056347287397152,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}