{"id":"W2010894264","doi":"10.1242/dev.099796","title":"Novel cardiovascular gene functions revealed via systematic phenotype prediction in zebrafish","year":2013,"lang":"en","type":"article","venue":"Development","topic":"Congenital heart defects research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Toronto","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; Harvard Stem Cell Institute; University of California, San Francisco; University of Toronto; Howard Hughes Medical Institute; Williams College; Fondation Leducq; National Heart, Lung, and Blood Institute; National Human Genome Research Institute; Canada Excellence Research Chairs, Government of Canada; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Institutes of Health; National Science Foundation","keywords":"Biology; Zebrafish; Phenotype; Morpholino; Gene knockdown; Computational biology; Gene; Genetics; Loss function; Genetic screen; Model organism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004435566,0.0006490917,0.0003702452,0.0005467745,0.0002333153,0.0002615023,0.0002427313,0.0002255466,0.0005064976],"category_scores_gemma":[0.0004627846,0.0002286503,0.0003613087,0.0002296803,0.0003012918,0.0001797491,0.0003183305,0.0004069221,0.0002408038],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000363028,"about_ca_system_score_gemma":0.000564914,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001679954,"about_ca_topic_score_gemma":0.004021342,"domain_scores_codex":[0.9998195,0.00002578349,0.00001403661,0.00005085844,0.00006818162,0.00002174061],"domain_scores_gemma":[0.9997792,0.00008604376,0.00007198226,0.00002095119,0.00002523097,0.00001665027],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009622412,0.00001338325,0.005804541,0.00004772566,0.00001674894,0.00009883875,0.0000156806,0.004755039,0.9796706,0.0001613365,0.00006914971,0.009250731],"study_design_scores_gemma":[0.00004936864,0.0004821953,0.08297238,0.0000165458,0.0001250361,0.0005023768,0.0000391411,0.08630476,0.8273184,0.0006986375,0.001434738,0.00005642638],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9543716,0.0004065468,0.04287693,0.00007008188,0.000006303689,0.00004739351,0.001165391,0.000517041,0.0005387203],"genre_scores_gemma":[0.9450443,0.0004115992,0.0519694,0.0000556042,0.000003255494,0.00006842121,0.001648386,0.00006477235,0.0007342547],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001679954,"threshold_uncertainty_score":0.003340364,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0126252677226724,"score_gpt":0.2182599964623876,"score_spread":0.2056347287397152,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}