{"id":"W2010908418","doi":"10.2174/1381612033392404","title":"Immune Modulation by Plasmid DNA-mediated Cytokine Gene Transfer","year":2003,"lang":"en","type":"review","venue":"Current Pharmaceutical Design","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Cancer Institute; Juvenile Diabetes Research Foundation International","keywords":"Immunology; DNA vaccination; Proinflammatory cytokine; Cytokine; Immune system; Naked DNA; Genetic enhancement; Biology; Medicine; Inflammation; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008540332,0.0007823917,0.001106248,0.0001586117,0.0001243316,0.00006142779,0.0006241071,0.0006176332,0.000457545],"category_scores_gemma":[0.00008933245,0.0006995961,0.0006024808,0.0004091593,0.0001919452,0.000007487943,0.00008492253,0.0008265003,0.0003133057],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001176857,"about_ca_system_score_gemma":0.0004877487,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":3.153501e-7,"about_ca_topic_score_gemma":1.868372e-7,"domain_scores_codex":[0.9953902,0.001344935,0.000866777,0.001015012,0.0005308209,0.0008522494],"domain_scores_gemma":[0.9985345,0.000122547,0.000110006,0.0006577615,0.0001300092,0.0004451534],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006618832,0.0004268685,4.104105e-7,0.002219873,0.0004210174,0.000007034418,0.000004557938,0.00002600025,0.1807287,0.000007182345,0.007397104,0.8080993],"study_design_scores_gemma":[0.001090794,0.0007388624,1.540178e-7,0.0004224958,0.0003024653,0.0000187274,4.300265e-7,0.0002989095,0.1140354,0.000006904527,0.8824333,0.0006516012],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001639723,0.9755319,0.02122092,0.00002369538,0.0005743327,0.001833589,0.0005420446,0.0000438898,0.00006567321],"genre_scores_gemma":[0.0003166425,0.9934286,0.00009192874,0.00008831846,0.0003514862,0.000383852,0.004945278,0.000173622,0.0002202947],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8750362,"threshold_uncertainty_score":0.9995455,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1362045699114157,"score_gpt":0.4152860338875173,"score_spread":0.2790814639761016,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}