{"id":"W2010923119","doi":"10.1038/npp.2011.105","title":"The Reduction of R1, a Novel Repressor Protein for Monoamine Oxidase A, in Major Depressive Disorder","year":2011,"lang":"en","type":"article","venue":"Neuropsychopharmacology","topic":"Nuclear Receptors and Signaling","field":"Neuroscience","cited_by":84,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital; University of Toronto; Centre for Addiction and Mental Health","funders":"National Center for Research Resources; Canadian Institutes of Health Research; National Institute of Mental Health; National Alliance for Research on Schizophrenia and Depression","keywords":"Major depressive disorder; Antidepressant; Monoamine oxidase; Internal medicine; Prefrontal cortex; Endocrinology; Monoamine neurotransmitter; Monoamine oxidase B; Psychology; Medicine; Psychiatry; Serotonin; Biology; Receptor; Cognition; Biochemistry; Hippocampus; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001353815,0.0002959678,0.0003274897,0.0001886391,0.0001974817,0.0002252902,0.0003017569,0.0004762159,0.001353993],"category_scores_gemma":[0.0002445863,0.0002277337,0.0003481763,0.0001116914,0.0004419484,0.0001091538,0.0001601231,0.0007870972,0.0003913788],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004616243,"about_ca_system_score_gemma":0.0002309537,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001655295,"about_ca_topic_score_gemma":0.002170726,"domain_scores_codex":[0.9998821,0.00002070434,0.00001098794,0.00002713758,0.0000250073,0.00003404608],"domain_scores_gemma":[0.9998806,0.00001244082,0.00004109245,0.00001148443,0.00001057347,0.00004380243],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008463074,0.00005764074,0.0005739672,0.00004997451,0.0000277974,0.000141555,0.00002205613,0.0000670638,0.9954101,0.0001413522,0.0002563378,0.002405824],"study_design_scores_gemma":[0.0005035409,0.002033996,0.08350053,0.00002967795,0.000214957,0.004554902,0.0002257821,0.001747247,0.9003651,0.0004757101,0.006320819,0.00002771927],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957294,0.00135982,0.001176015,0.0003911971,0.00009292943,0.00001432909,0.0004446932,0.0000571423,0.0007343787],"genre_scores_gemma":[0.9968682,0.0005310675,0.0006708532,0.0001527494,0.00001513502,0.00001294911,0.0003550338,0.00001968025,0.001374303],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001655295,"threshold_uncertainty_score":0.004529536,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04242779913561407,"score_gpt":0.3009756145116633,"score_spread":0.2585478153760492,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}