{"id":"W2010947980","doi":"10.1097/00001813-200203000-00007","title":"The doxorubicin cardioprotective agent dexrazoxane (ICRF-187) induces endopolyploidy in rat neonatal myocytes through inhibition of DNA topoisomerase II","year":2002,"lang":"en","type":"article","venue":"Anti-Cancer Drugs","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"","keywords":"Dexrazoxane; Topoisomerase; Doxorubicin; Myocyte; Cardiotoxicity; Pharmacology; Flow cytometry; Biology; Chemistry; Cell biology; DNA; Molecular biology; Biochemistry; Anthracycline; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001727068,0.0002260467,0.0002624981,0.00004660924,0.0002218685,0.00002657684,0.0001926691,0.0001427775,0.00004877738],"category_scores_gemma":[0.00001350581,0.0001826302,0.0001521142,0.0002054272,0.0001342448,0.00001619819,0.0001492294,0.0001649472,0.000004726681],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006914168,"about_ca_system_score_gemma":0.00005797076,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006693708,"about_ca_topic_score_gemma":0.0003894377,"domain_scores_codex":[0.9986216,0.00007224206,0.0003205812,0.000401412,0.0002259005,0.0003582038],"domain_scores_gemma":[0.9993063,0.00001929195,0.000163735,0.0003737294,0.00008854978,0.00004841706],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009088252,0.00007519349,0.00006913512,0.00001753577,0.0000838007,0.000004262985,0.001329097,0.00005148293,0.9757832,0.0003365466,0.000237243,0.02192157],"study_design_scores_gemma":[0.001104809,0.0002511656,0.00007119444,0.00004510631,0.00002787041,0.000005693028,0.0009169912,0.00002926731,0.9632759,0.0003175451,0.03373408,0.0002203628],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852057,0.01268409,0.0001440629,0.0005766129,0.0004369541,0.000428086,0.00005847059,0.00001172232,0.0004542812],"genre_scores_gemma":[0.9860612,0.01238877,0.00005344174,0.0004235425,0.0002742832,0.0001490543,0.0000264185,0.00002964768,0.0005936644],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03349684,"threshold_uncertainty_score":0.7447445,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01661729173243212,"score_gpt":0.2512402859184167,"score_spread":0.2346229941859846,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}