{"id":"W2010949873","doi":"10.1002/cncr.21023","title":"A phase II trial of R115777, an oral farnesyl transferase inhibitor, in patients with advanced urothelial tract transitional cell carcinoma","year":2005,"lang":"en","type":"article","venue":"Cancer","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Chemotherapy; Neutropenia; Regimen; Febrile neutropenia; Internal medicine; Gastroenterology; Chemotherapy regimen; Oncology; Pharmacology; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009390577,0.001068746,0.001391076,0.000306968,0.000344564,0.0006084137,0.0004964361,0.0007692688,0.001948176],"category_scores_gemma":[0.0005250701,0.0003131957,0.0007240084,0.0003125562,0.0006504215,0.0004400422,0.0002793057,0.001722102,0.0004511405],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005497112,"about_ca_system_score_gemma":0.001114463,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007687507,"about_ca_topic_score_gemma":0.001510037,"domain_scores_codex":[0.9997504,0.0001200202,0.00001630924,0.00003242054,0.00002738764,0.00005334992],"domain_scores_gemma":[0.9995255,0.00008696226,0.0000790765,0.00003074522,0.000030083,0.0002476205],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5494758,0.06366558,0.02878191,0.002025467,0.001919159,0.001262255,0.0008286986,0.006239444,0.125193,0.0003653101,0.004368756,0.2158746],"study_design_scores_gemma":[0.3901478,0.5727509,0.02312425,0.00004595357,0.0006325204,0.0006604592,0.0001209543,0.002522455,0.007706748,0.0001099227,0.002146937,0.00003113327],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973099,0.001076937,0.000187458,0.0001418062,0.00003703355,0.0005383303,0.0001339846,0.00003029499,0.0005442863],"genre_scores_gemma":[0.996354,0.0009189115,0.0005656563,0.0002732485,0.00007289772,0.0004959446,0.0006751231,0.000008337173,0.000635864],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001948176,"threshold_uncertainty_score":0.006517291,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008782618151394304,"score_gpt":0.258818454460269,"score_spread":0.2500358363088747,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}