{"id":"W2010949873","doi":"10.1002/cncr.21023","title":"A phase II trial of R115777, an oral farnesyl transferase inhibitor, in patients with advanced urothelial tract transitional cell carcinoma","year":2005,"lang":"en","type":"article","venue":"Cancer","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Chemotherapy; Neutropenia; Regimen; Febrile neutropenia; Internal medicine; Gastroenterology; Chemotherapy regimen; Oncology; Pharmacology; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007417957,0.00014031,0.0001614478,0.0000511529,0.00004609816,0.000005735377,0.00006916989,0.00009589128,0.00009007431],"category_scores_gemma":[0.000003962964,0.0001272594,0.0000656429,0.00008132604,0.00005227091,0.00001570376,0.000006424549,0.00007365064,4.873431e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002781684,"about_ca_system_score_gemma":0.0001835649,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002264079,"about_ca_topic_score_gemma":0.00009221602,"domain_scores_codex":[0.9991244,0.00004783806,0.000235397,0.0002616035,0.000161624,0.0001691587],"domain_scores_gemma":[0.9996387,0.0000026455,0.00005693865,0.0001418745,0.00007900305,0.00008077579],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0684524,0.006377494,0.001301427,0.00004345983,0.00001722011,0.000004185528,0.0003874899,0.002809459,0.8572871,0.00002312954,0.00003123314,0.06326542],"study_design_scores_gemma":[0.1715003,0.006573366,0.002012199,0.00002904601,0.00002610407,7.365814e-7,0.0000198662,0.0001966251,0.8142886,0.000006814214,0.005078527,0.0002678812],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998311,0.0002655272,0.0004858102,0.00006248816,0.00006211437,0.0005355157,0.0002011895,0.00000617578,0.00007017271],"genre_scores_gemma":[0.9988195,0.00001172678,0.0003866534,0.0001226992,0.000262122,0.00008407224,0.0002562083,0.00001982123,0.00003724529],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1030479,"threshold_uncertainty_score":0.5189486,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008782618151394304,"score_gpt":0.258818454460269,"score_spread":0.2500358363088747,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}