{"id":"W2010980589","doi":"10.1016/j.bmcl.2010.02.010","title":"Design and synthesis of boron-containing PDE4 inhibitors using soft-drug strategy for potential dermatologic anti-inflammatory application","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":false,"ca_institutions":"NAEJA-RGM Pharmaceuticals (Canada)","funders":"","keywords":"Chemistry; Limiting; Drug; Potency; Pharmacology; Combinatorial chemistry; Enzyme; Anti-inflammatory; Stereochemistry; In vitro; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000255143,0.0001750202,0.0001911749,0.00002495764,0.0001081476,0.00001428953,0.0001050163,0.0001814107,0.00001225712],"category_scores_gemma":[0.00007288131,0.0001635553,0.00005796435,0.00005067684,0.0001954184,0.000009203549,0.00003605967,0.0001120474,4.705774e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001626588,"about_ca_system_score_gemma":0.00008830811,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001046502,"about_ca_topic_score_gemma":0.000001224008,"domain_scores_codex":[0.9990384,0.00002680813,0.0002908464,0.0003189672,0.0001288706,0.0001961224],"domain_scores_gemma":[0.9993812,0.00003877307,0.0002174754,0.000205646,0.00007013618,0.00008670741],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001078105,0.00002397845,0.001048798,0.0001232885,0.00003998199,0.000002391388,0.00002779152,0.0001473033,0.9971095,0.000001917943,0.000358562,0.001008703],"study_design_scores_gemma":[0.0005490256,0.00002288551,0.0008300026,0.00002978239,0.00007542231,0.0001119265,0.0001424174,0.002241574,0.9954906,0.00000786839,0.0003249429,0.0001735865],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9281445,0.0002019419,0.07080366,0.0004352326,0.0001492475,0.0002328187,0.000006494651,0.00001813621,0.000008003548],"genre_scores_gemma":[0.9978318,0.00002310621,0.001487892,0.0001777975,0.000368402,0.00002554782,0.00005425569,0.00002238772,0.000008853214],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0696873,"threshold_uncertainty_score":0.6669593,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008844010666857412,"score_gpt":0.2254499124102605,"score_spread":0.2166059017434031,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}