{"id":"W2011001330","doi":"10.1371/journal.pgen.0030192","title":"Identification of Two Independent Risk Factors for Lupus within the MHC in United Kingdom Families","year":2007,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":171,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"Anthony Nolan; National Institute of Allergy and Infectious Diseases; Broad Institute; Wellcome Trust; National Institute of Diabetes and Digestive and Kidney Diseases; Versus Arthritis; National Center for Research Resources; Cancer Research Institute","keywords":"Biology; Genetics; Linkage disequilibrium; Allele; Major histocompatibility complex; Single-nucleotide polymorphism; Locus (genetics); Human leukocyte antigen; MHC class I; Haplotype; Genetic association; SNP; Genotype; Gene; Antigen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005117639,0.0001496774,0.0002110918,0.0002376625,0.000137647,0.000008923722,0.0003189349,0.0002321954,0.00002150306],"category_scores_gemma":[0.0001525228,0.0001082979,0.00006687923,0.0002438584,0.0002765395,0.00002259292,0.00007411231,0.0002928913,0.0000286837],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003329791,"about_ca_system_score_gemma":0.00003334416,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000253152,"about_ca_topic_score_gemma":0.0007101129,"domain_scores_codex":[0.9987556,0.0001391187,0.0005586753,0.0002155827,0.00004585688,0.0002851998],"domain_scores_gemma":[0.998721,0.0004553981,0.0003531833,0.0003455082,0.0001138989,0.00001102709],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000995251,0.0001921233,0.07130616,0.00001560826,0.0001278253,5.341018e-7,0.001794454,0.0002697722,0.9252605,0.0006515096,0.00003640778,0.0002455453],"study_design_scores_gemma":[0.001262479,0.0001375852,0.007571484,0.0000133187,0.00009028837,0.000006067613,0.001711411,0.0001586289,0.9869131,0.0006694383,0.00134172,0.0001244472],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967853,0.000950376,0.0006743575,0.00002900277,0.0009985671,0.0004333163,0.0000547006,0.00002613932,0.00004822449],"genre_scores_gemma":[0.9991906,0.0001079663,0.00004985635,0.0000293336,0.00001857187,0.00001622853,0.0001104135,0.00001719457,0.0004598299],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06373468,"threshold_uncertainty_score":0.441626,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0290712326228201,"score_gpt":0.26054017823435,"score_spread":0.2314689456115299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}