{"id":"W2011023406","doi":"10.1007/s12035-014-9074-1","title":"Transcriptional Regulation of Brain-Derived Neurotrophic Factor (BDNF) by Methyl CpG Binding Protein 2 (MeCP2): a Novel Mechanism for Re-Myelination and/or Myelin Repair Involved in the Treatment of Multiple Sclerosis (MS)","year":2015,"lang":"en","type":"review","venue":"Molecular Neurobiology","topic":"Neurogenesis and neuroplasticity mechanisms","field":"Neuroscience","cited_by":73,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba; Research Manitoba","funders":"","keywords":"Remyelination; Myelin; Multiple sclerosis; Neurotrophic factors; Immunology; Neuroscience; Brain-derived neurotrophic factor; Neuroinflammation; Myelin basic protein; Biology; Cancer research; Medicine; Cell biology; Central nervous system; Inflammation; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003883207,0.0007302068,0.0009045989,0.0009875087,0.0001319244,0.0005442553,0.0005697659,0.0006562137,0.001387178],"category_scores_gemma":[0.0003111016,0.000184758,0.0002508577,0.0009917406,0.0003544019,0.000671721,0.0004806155,0.001199476,0.000961011],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004492045,"about_ca_system_score_gemma":0.0006800253,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009745414,"about_ca_topic_score_gemma":0.002248492,"domain_scores_codex":[0.9999166,0.00000953315,0.00001326683,0.00001922677,0.00003051685,0.00001089705],"domain_scores_gemma":[0.999886,0.00004268845,0.00002473225,0.000003388117,0.0000289642,0.00001420746],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000114914,0.00005185094,0.0002120941,0.01086054,0.0001025268,0.0001906519,0.00004079024,0.0004069662,0.009187926,0.003339961,0.0190378,0.9564539],"study_design_scores_gemma":[0.00003753898,0.0001053868,0.001510064,0.001801625,0.0001769817,0.001099528,0.00004628845,0.0001260451,0.00260475,0.00207273,0.9903948,0.00002434364],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002293238,0.9986089,0.0002533546,0.0001833027,0.00013929,0.000003134108,0.00002771217,0.000007491151,0.000547496],"genre_scores_gemma":[0.00122531,0.9974837,0.0003109504,0.0001753659,0.0001134523,0.000004759281,0.00004998853,0.000001666573,0.0006348465],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001387178,"threshold_uncertainty_score":0.004640579,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1706867144547239,"score_gpt":0.3144665881358538,"score_spread":0.1437798736811299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}