{"id":"W2011023406","doi":"10.1007/s12035-014-9074-1","title":"Transcriptional Regulation of Brain-Derived Neurotrophic Factor (BDNF) by Methyl CpG Binding Protein 2 (MeCP2): a Novel Mechanism for Re-Myelination and/or Myelin Repair Involved in the Treatment of Multiple Sclerosis (MS)","year":2015,"lang":"en","type":"review","venue":"Molecular Neurobiology","topic":"Neurogenesis and neuroplasticity mechanisms","field":"Neuroscience","cited_by":73,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba; Research Manitoba","funders":"","keywords":"Remyelination; Myelin; Multiple sclerosis; Neurotrophic factors; Immunology; Neuroscience; Brain-derived neurotrophic factor; Neuroinflammation; Myelin basic protein; Biology; Cancer research; Medicine; Cell biology; Central nervous system; Inflammation; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004023186,0.0006915527,0.001675217,0.0005158459,0.0001225939,0.00002908849,0.0004858463,0.0004229409,0.00001051434],"category_scores_gemma":[0.001358297,0.0004893543,0.0006412631,0.0006467764,0.0001936676,0.00008736671,0.00006974369,0.0002625689,0.000001862068],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008718605,"about_ca_system_score_gemma":0.0001960105,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002015183,"about_ca_topic_score_gemma":0.00002021617,"domain_scores_codex":[0.9945838,0.001958622,0.001318922,0.001279697,0.0003913383,0.0004675524],"domain_scores_gemma":[0.9966043,0.001567131,0.0009878288,0.0005868816,0.0001560079,0.00009785323],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002349322,0.0005790681,3.960044e-7,0.001197876,0.0000303918,0.00001382816,0.00009002929,0.00001196587,0.9912887,0.002148792,0.00001296309,0.004391013],"study_design_scores_gemma":[0.00259151,0.004751222,0.00001091165,0.0007373187,0.0003326362,0.00005121901,0.00001234813,0.0008286459,0.9661657,0.0001696996,0.02388095,0.0004677924],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9030648,0.06552271,0.01098899,0.000426217,0.0007870698,0.01517248,0.003852923,0.0001783691,0.000006437852],"genre_scores_gemma":[0.3292422,0.6608826,0.002189484,0.001157975,0.0001421072,0.005132212,0.0006555118,0.0004688727,0.0001290206],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.5953599,"threshold_uncertainty_score":0.9997558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1706867144547239,"score_gpt":0.3144665881358538,"score_spread":0.1437798736811299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}