{"id":"W2011044258","doi":"10.1158/1538-7445.am2014-ct104","title":"Abstract CT104: Antitumor activity of the anti-PD-1 monoclonal antibody MK-3475 in melanoma(MEL): Correlation of tumor PD-L1 expression with outcome","year":2014,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Monoclonal antibody; Antibody; Dosing; Pharmacodynamics; Internal medicine; CD8; Immunohistochemistry; Gastroenterology; Immunology; Pharmacokinetics; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004099333,0.0003046374,0.0003659539,0.0002465413,0.0001192989,0.000211104,0.0001839005,0.0002676407,0.001763678],"category_scores_gemma":[0.0004286048,0.00007520051,0.0001533355,0.0001827239,0.0001969008,0.0001637261,0.0001164494,0.0005540213,0.0003047955],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005334253,"about_ca_system_score_gemma":0.0003358043,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009269838,"about_ca_topic_score_gemma":0.0008989148,"domain_scores_codex":[0.9998631,0.00003553872,0.0000119695,0.0000221341,0.00004030507,0.00002698686],"domain_scores_gemma":[0.9997349,0.00008297629,0.00005322773,0.00001320863,0.0000218848,0.00009363297],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.1526034,0.008474504,0.1797847,0.0007589137,0.0005314017,0.001020294,0.0001443413,0.005078614,0.4551499,0.0002332482,0.005835334,0.1903855],"study_design_scores_gemma":[0.009148006,0.226504,0.5801018,0.00006978343,0.0007033622,0.002881061,0.00006255603,0.008286712,0.165605,0.0002662324,0.006334375,0.00003705961],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970971,0.001020465,0.0003064744,0.00006814658,0.00001549643,0.0001094979,0.0003688733,0.00003081836,0.0009831308],"genre_scores_gemma":[0.9982924,0.0001597084,0.0002214466,0.00004490096,0.00001528464,0.00005153727,0.0005945788,0.000003781796,0.000616447],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001763678,"threshold_uncertainty_score":0.005900085,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05514992406310552,"score_gpt":0.4019696920424806,"score_spread":0.3468197679793751,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}