{"id":"W2011056838","doi":"10.1371/journal.pone.0015673","title":"Rat Hypocretin/Orexin Neurons Are Maintained in a Depolarized State by TRPC Channels","year":2010,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Sleep and Wakefulness Research","field":"Neuroscience","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University","funders":"","keywords":"TRPC5; TRPC; TRPC3; TRPC1; Transient receptor potential channel; Chemistry; Patch clamp; Cell biology; Internal medicine; Endocrinology; Mechanosensitive channels; Biophysics; Hyperpolarization (physics); Ion channel; Biology; Biochemistry; Receptor; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003116981,0.0002002137,0.0003169959,0.000170178,0.0001539112,0.0001421906,0.0005147567,0.00009928085,0.0002477587],"category_scores_gemma":[0.002646491,0.0001892071,0.00005216551,0.0006010291,0.0001876216,0.0001971902,0.0001761211,0.0009111903,0.0002379098],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002896454,"about_ca_system_score_gemma":0.00005675685,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000100354,"about_ca_topic_score_gemma":0.0001275508,"domain_scores_codex":[0.9974009,0.0002922014,0.0002785473,0.0005822616,0.0007038217,0.00074227],"domain_scores_gemma":[0.9986951,0.000455418,0.00008597099,0.0004641924,0.00005215472,0.0002471369],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000169075,0.001123762,0.003460051,0.00002731778,0.000007493511,0.0001420239,0.0001395399,0.000001835254,0.9939643,0.000119516,0.0002624376,0.0005826731],"study_design_scores_gemma":[0.001438912,0.0001052219,0.001034219,0.00004038936,0.000009676653,0.000005786651,0.00003246215,0.00226737,0.993654,0.0008424802,0.0003444133,0.0002251068],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958757,0.00002045635,0.00005086973,0.002432202,0.0001655552,0.0005982241,0.00006770171,0.0001187215,0.0006705719],"genre_scores_gemma":[0.9966365,0.00004138423,0.0001299247,0.0006611447,0.00007802143,0.0001633912,0.000007371696,0.00004748925,0.002234763],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002425832,"threshold_uncertainty_score":0.7715641,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05613105818809842,"score_gpt":0.2608094828377983,"score_spread":0.2046784246496998,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}