{"id":"W2011104528","doi":"10.1021/ja307060p","title":"Sinefungin Derivatives as Inhibitors and Structure Probes of Protein Lysine Methyltransferase SETD2","year":2012,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":149,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"National Institute of Neurological Disorders and Stroke; Canadian Institutes of Health Research; National Institute of General Medical Sciences; Wellcome Trust","keywords":"Methyltransferase; Chemistry; Epigenetics; Small molecule; Methylation; Lysine; Computational biology; Biochemistry; Gene; Amino acid; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001992716,0.0003096546,0.000251878,0.0002224963,0.0001511657,0.0001584016,0.0004584147,0.0003735883,0.001400898],"category_scores_gemma":[0.0002067905,0.0001745034,0.0001682737,0.0002091785,0.0001914198,0.0001706619,0.0001943002,0.0005924352,0.0001765346],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003767612,"about_ca_system_score_gemma":0.0002082471,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007468338,"about_ca_topic_score_gemma":0.002237228,"domain_scores_codex":[0.9998699,0.00003302258,0.00000708868,0.00002516367,0.00003943713,0.00002531642],"domain_scores_gemma":[0.9999219,0.00003000237,0.00001601597,0.00001201057,0.000008517112,0.00001164655],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003374443,0.0001297007,0.0002396884,0.00006445782,0.00001542096,0.00008726833,0.00002874452,0.001393387,0.9916187,0.0003982685,0.0001589272,0.005528023],"study_design_scores_gemma":[0.0001268058,0.0009866921,0.0008284368,0.000005939913,0.00001431184,0.0001273277,0.00001723965,0.002524859,0.9931772,0.0001072964,0.002075498,0.000008383093],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871766,0.001993724,0.00555801,0.0001888683,0.00004231822,0.0001133673,0.0004413415,0.0001306302,0.004355139],"genre_scores_gemma":[0.9931895,0.001311656,0.003416245,0.00007793238,0.000007554081,0.00005017987,0.000347585,0.00001268639,0.00158667],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001400898,"threshold_uncertainty_score":0.004686415,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005657572287212198,"score_gpt":0.2479946050526487,"score_spread":0.2423370327654365,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}