{"id":"W2011104528","doi":"10.1021/ja307060p","title":"Sinefungin Derivatives as Inhibitors and Structure Probes of Protein Lysine Methyltransferase SETD2","year":2012,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":149,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"National Institute of Neurological Disorders and Stroke; Canadian Institutes of Health Research; National Institute of General Medical Sciences; Wellcome Trust","keywords":"Methyltransferase; Chemistry; Epigenetics; Small molecule; Methylation; Lysine; Computational biology; Biochemistry; Gene; Amino acid; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001994486,0.0001042659,0.000199168,0.00000985703,0.00003380241,0.000008919232,0.0001259802,0.00006112947,0.000004578624],"category_scores_gemma":[0.0001404862,0.00006635847,0.0001980788,0.000132939,0.0002867866,0.000008848739,0.0000639443,0.000145971,7.725169e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001319726,"about_ca_system_score_gemma":0.00004309044,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009336426,"about_ca_topic_score_gemma":3.153357e-7,"domain_scores_codex":[0.9992933,0.00006177621,0.0002512283,0.00008551651,0.0001677129,0.0001404767],"domain_scores_gemma":[0.9993128,0.00002088683,0.0003566377,0.0001208876,0.000108551,0.0000803031],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004486937,0.0000464468,0.00713083,0.0000195513,0.00008887254,6.759937e-8,0.000237058,0.00001076706,0.9903666,0.000008695374,0.00007695879,0.001969316],"study_design_scores_gemma":[0.0002187213,0.0001476493,0.00408929,0.00002038422,0.00003842454,0.000007724619,0.0002121606,0.000005149183,0.9938278,0.0001919429,0.001161015,0.00007977308],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969166,0.002072831,0.0003937368,0.0004637768,0.00003853846,0.00009032568,0.000007576015,0.000001329434,0.00001529049],"genre_scores_gemma":[0.993544,0.0002158094,0.005819001,0.0001118901,0.0002788759,0.000001137297,0.000003227754,0.0000112364,0.00001484195],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005425264,"threshold_uncertainty_score":0.270602,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005657572287212198,"score_gpt":0.2479946050526487,"score_spread":0.2423370327654365,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}