{"id":"W2011113518","doi":"10.1038/onc.2012.312","title":"RSK regulates activated BRAF signalling to mTORC1 and promotes melanoma growth","year":2012,"lang":"en","type":"article","venue":"Oncogene","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"National Cancer Institute","keywords":"Biology; MAPK/ERK pathway; mTORC1; PI3K/AKT/mTOR pathway; Ribosomal s6 kinase; Neuroblastoma RAS viral oncogene homolog; Cell biology; Protein kinase A; Kinase; Melanoma; Cancer research; HRAS; Cell growth; MAPK cascade; RNA interference; Signal transduction; P70-S6 Kinase 1; Genetics; RNA; Mutation; Gene; KRAS","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001696196,0.0004478394,0.0001953086,0.0004349807,0.0003118951,0.00058161,0.0003420762,0.0002765183,0.00402074],"category_scores_gemma":[0.0002058837,0.0002696346,0.0004740744,0.0001885285,0.0003089224,0.0002578716,0.0003683731,0.0007744008,0.001909774],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006062187,"about_ca_system_score_gemma":0.0003361273,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009188202,"about_ca_topic_score_gemma":0.002349887,"domain_scores_codex":[0.9998178,0.0000281038,0.00001471319,0.00002896407,0.00004937199,0.00006111243],"domain_scores_gemma":[0.9998987,0.00001050311,0.00003697138,0.0000131059,0.00001163035,0.00002902758],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000809259,0.00008033585,0.0005384502,0.00008347856,0.00002002924,0.000124917,0.00001727361,0.0002195716,0.9940962,0.0006811343,0.0004966905,0.002832613],"study_design_scores_gemma":[0.0001193795,0.0003427453,0.0167222,0.00001702712,0.00006179947,0.0005734506,0.00008152553,0.002422805,0.9683282,0.0004142637,0.01089522,0.00002149193],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852207,0.003732234,0.001984593,0.0005039556,0.0001418531,0.00002775292,0.0007964582,0.0004146573,0.00717778],"genre_scores_gemma":[0.9926898,0.001101315,0.0007633561,0.00007999781,0.00002239226,0.00002474469,0.0005228109,0.00005993873,0.004735631],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00402074,"threshold_uncertainty_score":0.01345074,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0120354278908487,"score_gpt":0.2301806439107983,"score_spread":0.2181452160199496,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}