{"id":"W2011113518","doi":"10.1038/onc.2012.312","title":"RSK regulates activated BRAF signalling to mTORC1 and promotes melanoma growth","year":2012,"lang":"en","type":"article","venue":"Oncogene","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"National Cancer Institute","keywords":"Biology; MAPK/ERK pathway; mTORC1; PI3K/AKT/mTOR pathway; Ribosomal s6 kinase; Neuroblastoma RAS viral oncogene homolog; Cell biology; Protein kinase A; Kinase; Melanoma; Cancer research; HRAS; Cell growth; MAPK cascade; RNA interference; Signal transduction; P70-S6 Kinase 1; Genetics; RNA; Mutation; Gene; KRAS","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001573034,0.0001567641,0.0001391591,0.00003845574,0.000076856,0.00002074463,0.0001047827,0.0001358883,0.00003058879],"category_scores_gemma":[0.00005236711,0.0001411542,0.00004242943,0.00007691437,0.00002776965,0.000006991573,0.0001142043,0.0000487956,0.00003419874],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001051905,"about_ca_system_score_gemma":0.00002834063,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001729963,"about_ca_topic_score_gemma":0.000007265608,"domain_scores_codex":[0.9991418,0.0000401994,0.000136027,0.0002620092,0.00009118467,0.0003287611],"domain_scores_gemma":[0.9994706,0.00001237438,0.00004625419,0.000187078,0.00005293738,0.0002307473],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004450827,0.00005136316,0.003345144,0.00001606899,0.00003920396,0.000002353047,0.0001034063,0.000001877745,0.9922568,0.0001431144,0.0007202423,0.003275874],"study_design_scores_gemma":[0.0002485453,0.0003062414,0.001339569,0.00001347271,0.00001662367,0.00003396668,0.00002218275,0.000004938119,0.9688656,0.00004629516,0.02890329,0.000199316],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955215,0.00103147,0.0007443464,0.0001082832,0.0001181431,0.0001823229,0.00001330978,0.00002265005,0.002257935],"genre_scores_gemma":[0.9954819,0.0000483261,0.002698205,0.0002005525,0.0005538583,0.00002051217,0.00006697095,0.00002791622,0.0009017275],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02818305,"threshold_uncertainty_score":0.5756101,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0120354278908487,"score_gpt":0.2301806439107983,"score_spread":0.2181452160199496,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}