{"id":"W2011120782","doi":"10.1016/j.bmc.2007.05.065","title":"E,E,E-1-(4-Arylamino-4-oxo-2-butenoyl)-3,5-bis(arylidene)-4-piperidones: A topographical study of some novel potent cytotoxins","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":31,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan; Acadia University","funders":"","keywords":"Chemistry; Stereochemistry; Cytotoxicity; Cytotoxic T cell; Aryl; Structure–activity relationship; Potency; IC50; Cell culture; Melphalan; Leukemia; In vitro; Biochemistry; Multiple myeloma; Immunology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008889619,0.0001937652,0.0001104827,0.0001714108,0.0001278652,0.0001487373,0.0002198651,0.0001669804,0.001528707],"category_scores_gemma":[0.0000947093,0.00009094799,0.00008683005,0.0001191462,0.0001987307,0.0002235466,0.0001726632,0.0002404179,0.0003985843],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001249764,"about_ca_system_score_gemma":0.00009780219,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003116564,"about_ca_topic_score_gemma":0.0003657939,"domain_scores_codex":[0.9999617,0.000008333326,0.000002200481,0.000005511439,0.000006262635,0.00001592113],"domain_scores_gemma":[0.9999622,0.00001032236,0.000009417593,0.000004499501,0.000004043794,0.000009489411],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004462067,0.0001031881,0.000251185,0.0001385755,0.000005705856,0.0002806723,0.00007384797,0.0005541265,0.9832937,0.001690924,0.0002508161,0.01291099],"study_design_scores_gemma":[0.00009788171,0.001833717,0.003365937,0.00001105805,0.00001781488,0.0007493826,0.00007391142,0.001067138,0.9803886,0.0002291815,0.01215548,0.000009815648],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9762759,0.006795973,0.005957712,0.0001543433,0.00006216313,0.00004560682,0.0002626194,0.0001327308,0.01031293],"genre_scores_gemma":[0.9903507,0.003099833,0.002321556,0.00004468809,0.00002343051,0.00003362814,0.0001884312,0.00001196912,0.003925887],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001528707,"threshold_uncertainty_score":0.005114019,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02239093205036509,"score_gpt":0.2480397213290611,"score_spread":0.2256487892786961,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}