{"id":"W2011120782","doi":"10.1016/j.bmc.2007.05.065","title":"E,E,E-1-(4-Arylamino-4-oxo-2-butenoyl)-3,5-bis(arylidene)-4-piperidones: A topographical study of some novel potent cytotoxins","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":31,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan; Acadia University","funders":"","keywords":"Chemistry; Stereochemistry; Cytotoxicity; Cytotoxic T cell; Aryl; Structure–activity relationship; Potency; IC50; Cell culture; Melphalan; Leukemia; In vitro; Biochemistry; Multiple myeloma; Immunology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0007996878,0.0005854216,0.0009257825,0.00007742033,0.0001764991,0.0000266834,0.0008395348,0.0006197608,0.002519624],"category_scores_gemma":[0.0004948105,0.0004487996,0.0003108208,0.0004418391,0.000429298,0.0001118081,0.000314939,0.0007384775,0.00001595124],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001837438,"about_ca_system_score_gemma":0.0001446609,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002242848,"about_ca_topic_score_gemma":0.00002167919,"domain_scores_codex":[0.9961091,0.00002352642,0.001065239,0.0009576874,0.001008122,0.0008363724],"domain_scores_gemma":[0.9976652,0.0003318273,0.000445489,0.0008993321,0.0001694069,0.0004887324],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003139917,0.002956257,0.01418383,0.0002440252,0.0001611761,0.0001447232,0.0002140512,2.153041e-7,0.977514,0.0000285282,0.0001077628,0.004131471],"study_design_scores_gemma":[0.002114203,0.0003043703,0.02679692,0.000151254,0.0001958322,0.0001914164,0.005367738,0.00001187238,0.9629514,0.0000533025,0.001296551,0.0005650984],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937919,0.0006996029,0.0001139911,0.0001951361,0.0001511609,0.0002024667,0.0000533776,0.0001873691,0.004604958],"genre_scores_gemma":[0.997807,0.00007549555,0.0001269939,0.0001456696,0.001221211,0.00002156345,0.00002936788,0.00005134709,0.000521405],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01456253,"threshold_uncertainty_score":0.9997964,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02239093205036509,"score_gpt":0.2480397213290611,"score_spread":0.2256487892786961,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}