{"id":"W2011141313","doi":"10.1038/ncb2850","title":"Making a knockout mouse: From stem cells to embryos","year":2013,"lang":"en","type":"article","venue":"Nature Cell Biology","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Germline; Induced pluripotent stem cell; Biology; Stem cell; Genetics; Homologous recombination; Blastocyst; Embryonic stem cell; Gene; Embryogenesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002200199,0.00091316,0.0008572993,0.001671198,0.0008284682,0.001570071,0.001778566,0.001704433,0.003544236],"category_scores_gemma":[0.001649171,0.001617454,0.0008383037,0.0004888069,0.001647059,0.001621858,0.001296085,0.004766542,0.002857115],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000520997,"about_ca_system_score_gemma":0.0008878752,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004290318,"about_ca_topic_score_gemma":0.0007624744,"domain_scores_codex":[0.9986773,0.0001536201,0.0001983294,0.0002486493,0.0005999313,0.0001221348],"domain_scores_gemma":[0.9983375,0.0004323759,0.0003018276,0.0003853287,0.0002183172,0.0003246601],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008065702,0.00003639656,0.0002950407,0.00009974945,0.00002027689,0.0001978767,0.00006876129,0.0002570275,0.9837492,0.005314986,0.0008096877,0.00907029],"study_design_scores_gemma":[0.00005187764,0.000170297,0.0009568198,0.00007894019,0.00009892022,0.00107397,0.00006943869,0.0007275812,0.9602173,0.00291405,0.03360549,0.00003538861],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.2888462,0.00960758,0.6575387,0.009989387,0.003228919,0.001142502,0.00542938,0.008831327,0.01538601],"genre_scores_gemma":[0.3918699,0.01584369,0.5465559,0.003307981,0.0004326135,0.0009475632,0.004834999,0.005393919,0.03081349],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.003544236,"threshold_uncertainty_score":0.01185668,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01259718322780454,"score_gpt":0.2778823294494447,"score_spread":0.2652851462216401,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}