{"id":"W2011178421","doi":"10.1021/jm058235e","title":"Estradiol−Adenosine Hybrid Compounds Designed to Inhibit Type 1 17β-Hydroxysteroid Dehydrogenase","year":2005,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Hormonal Regulation and Hypertension","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Chemistry; Moiety; Hydroxysteroid dehydrogenase; Stereochemistry; Dehydrogenase; Cofactor; Enzyme; Adenosine; Substrate (aquarium); Binding site; Methylene; Estrogen; Biochemistry; Medicinal chemistry; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004274958,0.0001967045,0.0005349568,0.00009085576,0.00005750874,0.00001656819,0.0001395783,0.00009953905,0.0003761145],"category_scores_gemma":[0.0002835201,0.0001516018,0.0001343457,0.0001947193,0.00006813115,0.00009283831,0.00002214552,0.0004074862,0.00004790227],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000243375,"about_ca_system_score_gemma":0.0002768929,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002890277,"about_ca_topic_score_gemma":3.646346e-7,"domain_scores_codex":[0.9980565,0.00002243438,0.0006664451,0.0001702094,0.0008309289,0.000253491],"domain_scores_gemma":[0.9982881,0.00006075572,0.0002603126,0.0001935772,0.0004253,0.0007719674],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008274975,0.0001926024,0.0003056854,0.00005763398,0.00007247768,0.0006365252,0.00007007056,0.00002947895,0.9223188,0.000001253203,0.07028869,0.005199357],"study_design_scores_gemma":[0.003267423,0.0009158687,0.0008494151,0.0005626525,0.0002468254,0.02033081,0.00007880374,0.0003401912,0.856487,0.0000151326,0.116721,0.0001849024],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9844019,0.003162285,0.0004320106,0.01004206,0.0001036351,0.0001025105,0.000003379835,0.00002000553,0.001732171],"genre_scores_gemma":[0.9936751,0.000107799,0.001180588,0.00222072,0.00141352,9.485161e-7,0.00001796266,0.00002654558,0.001356838],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06583176,"threshold_uncertainty_score":0.6182142,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01816232006520032,"score_gpt":0.2743495890049718,"score_spread":0.2561872689397715,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}