{"id":"W2011178421","doi":"10.1021/jm058235e","title":"Estradiol−Adenosine Hybrid Compounds Designed to Inhibit Type 1 17β-Hydroxysteroid Dehydrogenase","year":2005,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Hormonal Regulation and Hypertension","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Chemistry; Moiety; Hydroxysteroid dehydrogenase; Stereochemistry; Dehydrogenase; Cofactor; Enzyme; Adenosine; Substrate (aquarium); Binding site; Methylene; Estrogen; Biochemistry; Medicinal chemistry; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001107447,0.0003576545,0.0003763773,0.0001484966,0.00008428835,0.0002222536,0.000257926,0.0003111763,0.001246365],"category_scores_gemma":[0.0001263675,0.0001782903,0.0001410689,0.0001498141,0.0001257923,0.0001303295,0.0001374406,0.000393301,0.000335205],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001631735,"about_ca_system_score_gemma":0.0000960317,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002610832,"about_ca_topic_score_gemma":0.0006848308,"domain_scores_codex":[0.9999131,0.00001830942,0.000006466789,0.00002211613,0.00002131247,0.00001873027],"domain_scores_gemma":[0.9999304,0.00002028988,0.00001748414,0.000006073365,0.000008973318,0.00001673091],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004571268,0.0001205419,0.0001496293,0.0001042941,0.00004074857,0.00008375924,0.00001785291,0.0006633298,0.9908484,0.0002426855,0.00009832977,0.007173277],"study_design_scores_gemma":[0.0002207061,0.002687202,0.001048488,0.00000852043,0.00006213663,0.0001882657,0.000009890869,0.0009819566,0.9875814,0.00004653495,0.007152862,0.00001204431],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9868832,0.004803654,0.003974705,0.00006624969,0.0001015442,0.0001671999,0.0004567672,0.0001186147,0.003428044],"genre_scores_gemma":[0.9848859,0.002545036,0.007493994,0.0001277619,0.00003073462,0.0001146419,0.0009457188,0.00002154696,0.003834635],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001246365,"threshold_uncertainty_score":0.004169524,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01816232006520032,"score_gpt":0.2743495890049718,"score_spread":0.2561872689397715,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}