{"id":"W2011235873","doi":"10.1089/jir.2012.0010","title":"Individual Interferon Regulatory Factor-3 Thiol Residues Are Not Critical for Its Activation Following Virus Infection","year":2012,"lang":"en","type":"article","venue":"Journal of Interferon & Cytokine Research","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Canadian Institutes of Health Research; Institut National de la Santé et de la Recherche Médicale; McMaster University","keywords":"Interferon; Transcription factor; Interferon regulatory factors; Sendai virus; Cell biology; Biology; Phosphorylation; Cysteine; IRF1; Innate immune system; Signal transduction; Chemistry; Biochemistry; Receptor; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.004210072,0.0003350778,0.000669752,0.001189149,0.0004585769,0.0001261334,0.0005633949,0.0005430887,0.0005527911],"category_scores_gemma":[0.00475309,0.0002745831,0.0005135418,0.0002815811,0.0002605264,0.001258515,0.000301898,0.001928992,0.0001985526],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005326343,"about_ca_system_score_gemma":0.0002173911,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004560727,"about_ca_topic_score_gemma":0.00002347325,"domain_scores_codex":[0.9955526,0.001556362,0.001073839,0.0003005651,0.0004079821,0.00110865],"domain_scores_gemma":[0.9956653,0.002154469,0.0004365584,0.0003482001,0.001260625,0.0001348194],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009603821,0.0005357315,0.002701314,0.0001077276,0.0005381909,0.000006051011,0.001321458,0.000002242135,0.9696631,0.0004582669,0.01205135,0.003010788],"study_design_scores_gemma":[0.001677328,0.004377032,0.03707486,0.0007545204,0.00007249087,0.0001936486,0.0009768872,0.000003707869,0.93654,0.00004942005,0.0180227,0.0002573701],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917784,0.002476121,0.001351725,0.0009865307,0.002647052,0.0004250824,0.00005670042,0.00004278687,0.0002355395],"genre_scores_gemma":[0.9976457,0.0001644873,0.00006689678,0.0001376678,0.0006456577,0.00003842197,0.00002310547,0.00006143698,0.001216613],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03437355,"threshold_uncertainty_score":0.9999706,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1362698298193953,"score_gpt":0.411277155637528,"score_spread":0.2750073258181326,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}