{"id":"W2011263904","doi":"10.1002/ps.352","title":"Insecticidal arylalkylbenzhydrolpiperidines: novel inhibitors of voltage‐sensitive sodium and calcium channels in mammalian brain","year":2001,"lang":"en","type":"article","venue":"Pest Management Science","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"","keywords":"Veratridine; Sodium channel; Chemistry; Batrachotoxin; Depolarization; Biophysics; Radioligand; Allosteric regulation; Sodium; Synaptosome; Binding site; Calcium; Calcium channel; Voltage-dependent calcium channel; Activator (genetics); Biochemistry; Stereochemistry; Enzyme; Biology; Receptor; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001168964,0.0002321079,0.0002494879,0.001120275,0.000376634,0.0001382767,0.0008236659,0.00004286386,0.00002539249],"category_scores_gemma":[0.0005791318,0.0002195958,0.00004321098,0.003653565,0.00239979,0.0008871246,0.0007924744,0.0002856393,0.00002828875],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006181747,"about_ca_system_score_gemma":0.00006965153,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008258398,"about_ca_topic_score_gemma":0.00001307319,"domain_scores_codex":[0.9964902,0.00009958353,0.0003734828,0.001176349,0.0009499411,0.0009104041],"domain_scores_gemma":[0.9989615,0.0002850725,0.0001260665,0.0003397671,0.00005311327,0.000234445],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007958182,0.0002324175,0.006315324,0.00003595625,9.622876e-7,0.0005220113,0.000331611,0.0001695835,0.9899979,0.00152886,0.00007382176,0.000711953],"study_design_scores_gemma":[0.001050183,0.0002689621,0.02408022,0.00003479545,0.000006837409,0.0001310407,0.0002322906,0.008542966,0.964225,0.0001460243,0.001010039,0.0002716247],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931449,0.000008122372,0.00028491,0.002018841,0.000667364,0.0006113649,0.000005151209,0.00004501054,0.003214368],"genre_scores_gemma":[0.9966664,0.00008689642,0.0000290124,0.001964401,0.00005986137,0.00003401095,1.80151e-7,0.00001565928,0.001143576],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0257729,"threshold_uncertainty_score":0.8954856,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04839793888094936,"score_gpt":0.3246387501761991,"score_spread":0.2762408112952497,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}