{"id":"W2011283910","doi":"10.1038/ni.2225","title":"A CD74-dependent MHC class I endolysosomal cross-presentation pathway","year":2012,"lang":"en","type":"article","venue":"Nature Immunology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":152,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; Canada's Michael Smith Genome Sciences Centre","funders":"Canadian Institutes of Health Research","keywords":"CD74; MHC class I; Antigen processing; Cross-presentation; Antigen presentation; Major histocompatibility complex; Biology; CTL*; MHC class II; MHC restriction; Priming (agriculture); Cell biology; Immunology; C-C chemokine receptor type 7; Immune system; CD8; T cell; Chemokine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001536384,0.0005329677,0.0002496325,0.0003858487,0.0005292454,0.000831348,0.0003180417,0.0005379462,0.004105634],"category_scores_gemma":[0.0001614212,0.0001440548,0.0003193211,0.0001971213,0.0002867084,0.0006371621,0.0004954616,0.0008233563,0.002052387],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001702494,"about_ca_system_score_gemma":0.000930079,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001069938,"about_ca_topic_score_gemma":0.00125413,"domain_scores_codex":[0.9997539,0.00002487222,0.0000091791,0.00003594668,0.00006464258,0.0001115454],"domain_scores_gemma":[0.999878,0.000009097009,0.00002067331,0.0000128999,0.00004271612,0.00003665378],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003551677,0.00007740501,0.0003188871,0.0001238914,0.00002629743,0.0004447722,0.00002570168,0.0002484671,0.9748995,0.004834756,0.002862357,0.01578279],"study_design_scores_gemma":[0.00005477762,0.0001974101,0.007598781,0.0000311131,0.00003982418,0.001516596,0.000141133,0.003818102,0.9543691,0.001776222,0.03042215,0.00003482541],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.904611,0.01606073,0.0355162,0.003972785,0.001221338,0.0002115385,0.001485444,0.001138968,0.03578199],"genre_scores_gemma":[0.9617138,0.003587174,0.007931282,0.0005350586,0.0001332475,0.00005234963,0.001202509,0.00005356061,0.02479106],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004105634,"threshold_uncertainty_score":0.0137347,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009034185362656438,"score_gpt":0.2788919783131099,"score_spread":0.2698577929504534,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}