{"id":"W2011283910","doi":"10.1038/ni.2225","title":"A CD74-dependent MHC class I endolysosomal cross-presentation pathway","year":2012,"lang":"en","type":"article","venue":"Nature Immunology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":152,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; Canada's Michael Smith Genome Sciences Centre","funders":"Canadian Institutes of Health Research","keywords":"CD74; MHC class I; Antigen processing; Cross-presentation; Antigen presentation; Major histocompatibility complex; Biology; CTL*; MHC class II; MHC restriction; Priming (agriculture); Cell biology; Immunology; C-C chemokine receptor type 7; Immune system; CD8; T cell; Chemokine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0005949949,0.0004484916,0.0005299895,0.00033247,0.0004923368,0.0000509415,0.0006695059,0.002059092,0.002530744],"category_scores_gemma":[0.0003640964,0.0003973309,0.0002701389,0.0002799557,0.0005981362,0.0005852508,0.0002395757,0.002197819,0.002808558],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001338241,"about_ca_system_score_gemma":0.0001216622,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007622039,"about_ca_topic_score_gemma":0.00000893301,"domain_scores_codex":[0.9967301,0.0008232811,0.0005971294,0.0004602419,0.000101157,0.001288109],"domain_scores_gemma":[0.998215,0.0004886726,0.0002852306,0.0008048619,0.0001683844,0.00003784416],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002127858,0.0004511094,0.009407311,0.00001182504,0.0006851219,0.00001058689,0.0006829607,0.00000208508,0.9595531,0.01002754,0.001101224,0.01593928],"study_design_scores_gemma":[0.003323585,0.0002810164,0.09793401,0.00001742993,0.00003679477,0.0007472217,0.0003291164,6.336141e-7,0.6001021,0.0001505121,0.2966807,0.000396843],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8460599,0.1386073,0.0001104289,0.0004874566,0.008241266,0.0004157096,0.0000550927,0.0002821434,0.00574065],"genre_scores_gemma":[0.9859934,0.0005391646,0.00006434236,0.0007481884,0.0002189692,0.00009226528,0.0002698056,0.00006187962,0.01201196],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.359451,"threshold_uncertainty_score":0.9998478,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009034185362656438,"score_gpt":0.2788919783131099,"score_spread":0.2698577929504534,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}