{"id":"W2011296263","doi":"10.1371/journal.pbio.1000354","title":"Structural Basis for Fe–S Cluster Assembly and tRNA Thiolation Mediated by IscS Protein–Protein Interactions","year":2010,"lang":"en","type":"article","venue":"PLoS Biology","topic":"Metalloenzymes and iron-sulfur proteins","field":"Energy","cited_by":264,"is_retracted":false,"has_abstract":true,"ca_institutions":"Biotechnology Research Institute; McGill University","funders":"Argonne National Laboratory; Basic Energy Sciences; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Office of Science; Canadian Light Source; Eli Lilly and Company; U.S. Department of Energy","keywords":"Frataxin; Sulfurtransferase; Biology; Biochemistry; Transfer RNA; Cysteine; Scaffold protein; Sulfur metabolism; Iron–sulfur cluster; Allosteric regulation; Enzyme; RNA; Aconitase; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008157103,0.0003526611,0.0003221799,0.0001760569,0.0004201867,0.0003352718,0.0004516711,0.0004729019,0.001385337],"category_scores_gemma":[0.0001762105,0.0001737372,0.000395773,0.0001719467,0.0003325244,0.0002339798,0.0002935776,0.0004204722,0.0007184825],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007099843,"about_ca_system_score_gemma":0.0003502324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00152981,"about_ca_topic_score_gemma":0.001217932,"domain_scores_codex":[0.9999021,0.00001026813,0.000005263866,0.00002318621,0.00003366108,0.00002560717],"domain_scores_gemma":[0.9998975,0.0000121139,0.0000246907,0.000009314553,0.00001827507,0.0000382073],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000270638,0.00008666931,0.002598148,0.00009674304,0.00002884095,0.0007319104,0.0001028062,0.003653901,0.9870592,0.002749153,0.000431159,0.002190765],"study_design_scores_gemma":[0.000152433,0.0004688424,0.04094509,0.00004326268,0.00006242855,0.001393619,0.0003562043,0.07131404,0.8692182,0.002667228,0.01332362,0.00005519146],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951169,0.000335539,0.002016579,0.0001367209,0.00002059517,0.00001253962,0.0000632659,0.0001299687,0.002167827],"genre_scores_gemma":[0.9980497,0.00009701013,0.000854263,0.00002777702,0.000005699275,0.000008728265,0.0002004388,0.000009154893,0.0007471525],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00152981,"threshold_uncertainty_score":0.005151272,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01901972330704144,"score_gpt":0.2578451050949965,"score_spread":0.238825381787955,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}