{"id":"W2011324987","doi":"10.1016/j.stem.2007.10.011","title":"Wnt, Activin, and BMP Signaling Regulate Distinct Stages in the Developmental Pathway from Embryonic Stem Cells to Blood","year":2008,"lang":"en","type":"article","venue":"Cell stem cell","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":328,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network","funders":"National Heart, Lung, and Blood Institute","keywords":"Biology; Wnt signaling pathway; Embryonic stem cell; Cell biology; Bone morphogenetic protein; Stem cell; Activin type 2 receptors; Signal transduction; Bone morphogenetic protein 2; BMPR2; TGF beta signaling pathway; Transforming growth factor; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004162609,0.0003310153,0.000276241,0.00008328091,0.0002352261,0.00007075802,0.0005493172,0.0001914503,0.00003080595],"category_scores_gemma":[0.000003966075,0.0002698405,0.00008689092,0.0002016093,0.0001011551,0.00001064706,0.0004003634,0.000249341,0.00008078694],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004767715,"about_ca_system_score_gemma":0.0001723182,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007741122,"about_ca_topic_score_gemma":0.00007881512,"domain_scores_codex":[0.9975879,0.0002946934,0.0003407745,0.0007753679,0.0003969074,0.0006043269],"domain_scores_gemma":[0.999078,0.0001151123,0.0001094046,0.0004478612,0.00005083366,0.0001988254],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007725402,0.0001869827,0.00395574,0.00006651635,0.00002589322,0.0001493087,0.0008233743,0.0000764864,0.9931961,8.423363e-7,0.0005576663,0.0008838157],"study_design_scores_gemma":[0.0009297358,0.0001929576,0.002739185,0.00003044945,0.00001537273,0.00002479305,0.0009403743,0.00002299725,0.9839009,0.00000369492,0.01084436,0.0003552059],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949705,0.001788981,0.0001025488,0.00006205297,0.00009183842,0.0006078844,0.00007091828,0.00001681797,0.002288452],"genre_scores_gemma":[0.9904409,0.0003356959,0.0002743709,0.0001078694,0.000102154,0.0000483539,0.00005804611,0.00004907575,0.008583503],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01028669,"threshold_uncertainty_score":0.9999754,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01646506488426294,"score_gpt":0.2157945954961565,"score_spread":0.1993295306118936,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}