{"id":"W2011384588","doi":"10.1016/j.bmcl.2010.01.014","title":"Celecoxib analogs possessing a N-(4-nitrooxybutyl)piperidin-4-yl or N-(4-nitrooxybutyl)-1,2,3,6-tetrahydropyridin-4-yl nitric oxide donor moiety: Synthesis, biological evaluation and nitric oxide release studies","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Moiety; Pharmacophore; Prodrug; Stereochemistry; Celecoxib; Chemical synthesis; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002503589,0.001136824,0.001689923,0.0004085066,0.0006035588,0.0001115844,0.0004906403,0.0007498066,0.0007158835],"category_scores_gemma":[0.009132154,0.0008422495,0.0003490659,0.001239472,0.001120622,0.0002821303,0.0002245416,0.001936806,0.00006618412],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006422829,"about_ca_system_score_gemma":0.0008010201,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009324256,"about_ca_topic_score_gemma":0.00001246696,"domain_scores_codex":[0.9938403,0.000329294,0.001289684,0.00154655,0.001573318,0.001420826],"domain_scores_gemma":[0.995101,0.001503701,0.0006472184,0.001057608,0.0005609291,0.001129518],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008892769,0.0002510004,0.01419214,0.0008181324,0.0004637896,0.001034351,0.0001393758,0.000001610313,0.9759191,0.000003250977,0.003313321,0.002974683],"study_design_scores_gemma":[0.005147413,0.0001763411,0.06720812,0.00083166,0.002134238,0.002745003,0.001324023,0.0004801663,0.9168964,0.00004182129,0.001722226,0.001292562],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917141,0.003214935,0.00006327355,0.002832008,0.0004238934,0.001191997,0.00002896819,0.0003572823,0.0001735428],"genre_scores_gemma":[0.9930748,0.0008670391,0.0009480924,0.002431814,0.002027624,0.0002688792,0.0001145272,0.0001482036,0.000118983],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05902264,"threshold_uncertainty_score":0.9994028,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03171185026912064,"score_gpt":0.2998739986268409,"score_spread":0.2681621483577202,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}