{"id":"W2011384588","doi":"10.1016/j.bmcl.2010.01.014","title":"Celecoxib analogs possessing a N-(4-nitrooxybutyl)piperidin-4-yl or N-(4-nitrooxybutyl)-1,2,3,6-tetrahydropyridin-4-yl nitric oxide donor moiety: Synthesis, biological evaluation and nitric oxide release studies","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Moiety; Pharmacophore; Prodrug; Stereochemistry; Celecoxib; Chemical synthesis; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001893643,0.0002195055,0.0002620814,0.0001109437,0.000131485,0.0001197614,0.000197722,0.0001906628,0.001110928],"category_scores_gemma":[0.0001776462,0.0001127022,0.0001294409,0.0001229341,0.0001458165,0.0001739864,0.00007671892,0.0003171923,0.0001991097],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001112288,"about_ca_system_score_gemma":0.0002004646,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003088971,"about_ca_topic_score_gemma":0.0008579036,"domain_scores_codex":[0.999946,0.00001127606,0.000004902544,0.000006700829,0.00001192643,0.00001925824],"domain_scores_gemma":[0.9999355,0.00001384448,0.000014887,0.000007027735,0.000005747238,0.00002298007],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002528065,0.0003788184,0.0001819954,0.0001389042,0.00001508944,0.0002368248,0.0000346171,0.0004126287,0.9852998,0.0002326523,0.0001198014,0.01042092],"study_design_scores_gemma":[0.00145308,0.0151813,0.003353467,0.00002288157,0.00009659409,0.0007107602,0.0000415752,0.00112246,0.9725992,0.00008269035,0.005318371,0.00001757462],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993936,0.002548581,0.0008923549,0.00005712877,0.00004995359,0.00007702958,0.0001707243,0.0000276409,0.00224055],"genre_scores_gemma":[0.9936768,0.002100974,0.001474687,0.00006135622,0.00002558425,0.00005214004,0.0003877184,0.000005015662,0.002215736],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001110928,"threshold_uncertainty_score":0.003716469,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03171185026912064,"score_gpt":0.2998739986268409,"score_spread":0.2681621483577202,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}