{"id":"W2011421397","doi":"10.1371/journal.pone.0077027","title":"Reactive Oxygen Species Are Required for 5-HT-Induced Transactivation of Neuronal Platelet-Derived Growth Factor and TrkB Receptors, but Not for ERK1/2 Activation","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"University of Waterloo","keywords":"Transactivation; Platelet-derived growth factor receptor; Phosphorylation; Cell biology; Tropomyosin receptor kinase B; NADPH oxidase; Receptor tyrosine kinase; Biology; Apocynin; Tyrosine phosphorylation; Signal transduction; Receptor; Reactive oxygen species; Chemistry; Biochemistry; Growth factor; Transcription factor; Neurotrophic factors","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001144244,0.0002447858,0.0002155162,0.0001190513,0.0001269448,0.0002171066,0.0001337939,0.0002272851,0.001129282],"category_scores_gemma":[0.000133441,0.0001304605,0.0004212949,0.00007866575,0.0001000883,0.0001578468,0.000118002,0.0003633475,0.0003400407],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002131286,"about_ca_system_score_gemma":0.0001418984,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001322179,"about_ca_topic_score_gemma":0.001880022,"domain_scores_codex":[0.9998511,0.00002116825,0.00001786733,0.00002169513,0.00003918782,0.00004892543],"domain_scores_gemma":[0.9999084,0.000009694072,0.00003306927,0.00001027305,0.00001778823,0.00002080411],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001035694,0.0000194471,0.0001614475,0.00005541381,0.000008539212,0.00009767979,0.00001273588,0.00001560349,0.9988605,0.00005922692,0.00003281181,0.0005730507],"study_design_scores_gemma":[0.00002814223,0.0003333774,0.04199557,0.0000196126,0.00004365551,0.0007926039,0.00007667234,0.0006920697,0.9529715,0.00007088969,0.00296796,0.000007948788],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925639,0.003713601,0.001625327,0.0001238868,0.0000421057,0.00002846926,0.0004107016,0.00002976212,0.001462322],"genre_scores_gemma":[0.9951331,0.001340246,0.0009568781,0.00004471236,0.00001076836,0.00003403653,0.0007369281,0.000005580685,0.001737647],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001322179,"threshold_uncertainty_score":0.003777802,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05159574571061893,"score_gpt":0.2228240151605271,"score_spread":0.1712282694499082,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}