{"id":"W2011421397","doi":"10.1371/journal.pone.0077027","title":"Reactive Oxygen Species Are Required for 5-HT-Induced Transactivation of Neuronal Platelet-Derived Growth Factor and TrkB Receptors, but Not for ERK1/2 Activation","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"University of Waterloo","keywords":"Transactivation; Platelet-derived growth factor receptor; Phosphorylation; Cell biology; Tropomyosin receptor kinase B; NADPH oxidase; Receptor tyrosine kinase; Biology; Apocynin; Tyrosine phosphorylation; Signal transduction; Receptor; Reactive oxygen species; Chemistry; Biochemistry; Growth factor; Transcription factor; Neurotrophic factors","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007932383,0.0001694018,0.0002615298,0.00005156293,0.00009695075,0.00002701699,0.00008780565,0.0001865241,0.00005670473],"category_scores_gemma":[0.0002121932,0.0001645997,0.00008278695,0.00004534525,0.00002853862,0.00003203436,0.00001559252,0.00006378774,6.595973e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002134363,"about_ca_system_score_gemma":0.00003321612,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000024803,"about_ca_topic_score_gemma":0.000003223747,"domain_scores_codex":[0.9990216,0.00003225536,0.0002517038,0.0003387474,0.0001573582,0.0001982584],"domain_scores_gemma":[0.9991446,0.00007649867,0.0002372865,0.0001329972,0.0003465496,0.00006206847],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004742623,0.0001588092,0.00005501869,0.000114849,0.0001831087,3.470211e-8,0.0001476886,0.000001070646,0.9976972,0.0000520996,0.00005517697,0.001060637],"study_design_scores_gemma":[0.001015917,0.0007214937,0.002991449,0.00005639131,0.00003580305,2.895552e-7,0.0002292754,0.0001603536,0.9942738,0.0002468751,0.00008287296,0.0001854507],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870192,0.00001562009,0.01125463,0.0003203588,0.00005537797,0.001170253,0.0001308281,0.0000136531,0.00002012112],"genre_scores_gemma":[0.9941597,0.00004094732,0.004722321,0.00008350288,0.000211142,0.0002469704,0.0003008246,0.00003659053,0.000197999],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007140547,"threshold_uncertainty_score":0.6712183,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05159574571061893,"score_gpt":0.2228240151605271,"score_spread":0.1712282694499082,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}