{"id":"W2011446240","doi":"10.1161/01.cir.0000109484.00668.ce","title":"Unusual Effects of a QT-Prolonging Drug, Arsenic Trioxide, on Cardiac Potassium Currents","year":2003,"lang":"en","type":"article","venue":"Circulation","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":106,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; U.S. Public Health Service; Heart and Stroke Foundation of Canada","keywords":"Arsenic trioxide; hERG; Torsades de pointes; QT interval; Medicine; Potassium channel; Pharmacology; Acute promyelocytic leukemia; Afterdepolarization; Potassium channel blocker; Repolarization; Long QT syndrome; Internal medicine; Arsenic; Electrophysiology; Biochemistry; Chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001596745,0.00025613,0.0003438116,0.0001975735,0.000158617,0.0002214347,0.000156495,0.0003400121,0.0008702911],"category_scores_gemma":[0.0003422812,0.00009044721,0.0002470983,0.0001651634,0.0003005613,0.0002272639,0.000160662,0.0002816128,0.0002145426],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002372278,"about_ca_system_score_gemma":0.00008254973,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002637118,"about_ca_topic_score_gemma":0.0003657802,"domain_scores_codex":[0.9998666,0.00003247057,0.00001576049,0.00002689939,0.00003447244,0.00002381716],"domain_scores_gemma":[0.999821,0.00006158983,0.0000432999,0.00002854869,0.00002656446,0.00001907751],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003930989,0.00002089436,0.001768488,0.00007504713,0.00001486919,0.001515328,0.00004902009,0.000098497,0.9920954,0.0001679179,0.00007865728,0.003722703],"study_design_scores_gemma":[0.00009165493,0.001310309,0.02586156,0.0000116067,0.0001427113,0.02105437,0.0001326714,0.001292461,0.9454346,0.0003899287,0.004261171,0.00001691521],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922761,0.003118679,0.002723751,0.0001289409,0.0000284853,0.00002517389,0.000131418,0.0001089567,0.001458489],"genre_scores_gemma":[0.9980668,0.0007289908,0.0006990317,0.00005542187,0.00001709612,0.000009805163,0.00008032059,0.00001127857,0.0003312342],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008702911,"threshold_uncertainty_score":0.002911389,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005554774967433188,"score_gpt":0.2293009361216053,"score_spread":0.2237461611541721,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}