{"id":"W2011485062","doi":"10.1016/j.pbb.2015.03.014","title":"Hydroxycinnamic acid amide derivatives of polyamines reverse spermine-induced CNS excitation","year":2015,"lang":"en","type":"article","venue":"Pharmacology Biochemistry and Behavior","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Brock University","funders":"","keywords":"Spermine; NMDA receptor; Pharmacology; Chemistry; Excitotoxicity; Polyamine; Neuroprotection; Epilepsy; Receptor; Biochemistry; Medicine; Biology; Neuroscience","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001750929,0.0005587706,0.000326163,0.0003139676,0.0002072415,0.0002996449,0.0005570793,0.000476761,0.004278456],"category_scores_gemma":[0.000319487,0.0002155401,0.0002558554,0.0001766572,0.0005720112,0.0005028651,0.0001993625,0.001246615,0.0006844283],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004724742,"about_ca_system_score_gemma":0.0007202355,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001955796,"about_ca_topic_score_gemma":0.004051411,"domain_scores_codex":[0.9998825,0.00002170753,0.00001004309,0.00001780172,0.00002246919,0.00004551948],"domain_scores_gemma":[0.9995942,0.00008220514,0.00008813717,0.00005000327,0.00004970574,0.0001358081],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001251572,0.0001192163,0.0001195011,0.00007586523,0.00001517234,0.000110443,0.00003670927,0.00009390101,0.9931526,0.0004964508,0.00007704436,0.004451607],"study_design_scores_gemma":[0.000064912,0.001369097,0.001310958,0.000008981599,0.00002082948,0.00009235822,0.00003215827,0.0003080226,0.9956931,0.00006710833,0.001027051,0.000005542064],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878339,0.002524548,0.002572666,0.0001859769,0.0001902346,0.0001072494,0.000185032,0.0001339461,0.006266526],"genre_scores_gemma":[0.9903657,0.001842792,0.001244224,0.00008692099,0.0000680251,0.00003640955,0.0001990877,0.00003654759,0.00612033],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004278456,"threshold_uncertainty_score":0.01431286,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02896361437265378,"score_gpt":0.325744587500802,"score_spread":0.2967809731281482,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}