{"id":"W2011495769","doi":"10.1534/g3.111.000968","title":"Amino Acid Substitutions in the <i>Caenorhabditis elegans</i> RNA Polymerase II Large Subunit AMA-1/RPB-1 that Result in α-Amanitin Resistance and/or Reduced Function","year":2011,"lang":"en","type":"article","venue":"G3 Genes Genomes Genetics","topic":"Photosynthetic Processes and Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"National Institute of General Medical Sciences; National Institutes of Health; National Science Foundation","keywords":"Caenorhabditis elegans; Polymerase; Biology; Protein subunit; RNA polymerase; Genetics; Multicellular organism; RNA polymerase II; Saccharomyces cerevisiae; RNA; Gene; Gene expression; Promoter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009593394,0.0007711771,0.0001918188,0.0002524554,0.0003276808,0.0002357534,0.0002724758,0.0004735981,0.001398579],"category_scores_gemma":[0.000195577,0.000178125,0.0003746186,0.0001978262,0.0003758771,0.0001227178,0.0002100256,0.00055976,0.0007564526],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000488571,"about_ca_system_score_gemma":0.0003011476,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002227713,"about_ca_topic_score_gemma":0.004041738,"domain_scores_codex":[0.999923,0.00001063178,0.00001055619,0.00001859526,0.00002381839,0.0000133541],"domain_scores_gemma":[0.9997961,0.00004120203,0.00007072906,0.00001725929,0.00001819049,0.00005654673],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002650923,0.00004207623,0.0007921084,0.00005801919,0.00002649658,0.0008463633,0.00002305833,0.0003100585,0.9946046,0.0002040286,0.0002020279,0.002626069],"study_design_scores_gemma":[0.0001149468,0.0004049102,0.03283551,0.00005674502,0.0001506965,0.003456392,0.00007908264,0.001904149,0.9540163,0.0002975848,0.006638448,0.00004513041],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993258,0.0006327983,0.003005499,0.0001360259,0.0001127378,0.00004683726,0.0007610341,0.0001959553,0.001851163],"genre_scores_gemma":[0.9944261,0.0003693141,0.003348809,0.0001582022,0.0000202676,0.00001853054,0.0006304764,0.00005476177,0.0009734827],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002227713,"threshold_uncertainty_score":0.004678786,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02525798791808708,"score_gpt":0.2287880805100947,"score_spread":0.2035300925920077,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}