{"id":"W2011550644","doi":"10.1096/fj.08-120584","title":"Mouse models of cystathionine β‐synthase deficiency reveal significant threshold effects of hyperhomocysteinemia","year":2008,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":114,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute; National Institutes of Health","keywords":"Cystathionine beta synthase; Homocysteine; Hyperhomocysteinemia; Internal medicine; Endocrinology; Homocystinuria; Endoplasmic reticulum; Chemistry; Medicine; Methionine; Biology; Biochemistry; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002087095,0.001039457,0.0004665987,0.001037846,0.00028143,0.0005711477,0.0004591656,0.0008252516,0.003096244],"category_scores_gemma":[0.0001629724,0.0005177966,0.0005925236,0.0004849291,0.0005707836,0.0003432244,0.0004239013,0.001070697,0.001309755],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003295022,"about_ca_system_score_gemma":0.0002456337,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008195435,"about_ca_topic_score_gemma":0.001373048,"domain_scores_codex":[0.9996622,0.00003626822,0.00004907464,0.0001104023,0.00008541352,0.00005663057],"domain_scores_gemma":[0.9996019,0.00004483201,0.0001695839,0.00005027674,0.00003437386,0.00009911921],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003309919,0.00005930912,0.0004506171,0.0000463629,0.0000211003,0.0001813243,0.00003077451,0.00006627096,0.9971153,0.0002608372,0.00009963383,0.001337425],"study_design_scores_gemma":[0.0001377586,0.0007891954,0.0121025,0.00005075464,0.0001421893,0.002251907,0.0001128121,0.0008772874,0.9759228,0.0003791276,0.007209796,0.00002388497],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9755289,0.00276786,0.01129592,0.0004459597,0.00009179796,0.0001177348,0.005007303,0.0009264646,0.003818155],"genre_scores_gemma":[0.9674602,0.003658188,0.01104533,0.0002596371,0.00003647538,0.0002760933,0.004823098,0.0003050916,0.012136],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003096244,"threshold_uncertainty_score":0.01035798,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03284935674770909,"score_gpt":0.2716914463922841,"score_spread":0.238842089644575,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}